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High-Throughput Non-Targeted Metabolomics Study Of The Effects Of Perfluorooctane Sulfonate (Pfos) On The Metabolic Characteristics Of A. Thaliana Leaves

文献类型： 外文期刊

作者： Guo, QQ; He, ZY; Liu, XW; Liu, BJ; Zhang, YW

作者机构：

关键词： Pfos; Phytotoxicity; Metabolomics; Metabolic Mechanism

期刊名称： SCIENCE OF THE TOTAL ENVIRONMENT

ISSN： 0048-9697

年卷期： 2020 年 710 卷

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： The ecotoxicity of perfluorooctane sulfonate (PFOS) is complex and has been reported in animals (including fish and mice), but the effects of PFOS in plants. especially the toxic mechanisms, have rarely been studied. High-throughput nontargeted metabolomics methods for comprehensive assessment were selected to study changes in metabolic characteristics in Arabidopsis thaliana leaves by exposure to different concentrations of PFOS throughout the growth period (30 days). All the metabolites were analyzed by PCA and OPLS-DA methods, by the cutoff of VIP and p-value, 53 biomarkers were found and significantly regulated, all amino acids except glutamate were inhibited and probably associated with binding to protein, auxin and cytokinin of phytohormones were significantly down-regulated. In response mechanism to oxidative stress from Pros, the phenylpropanoid pathway were fully activated to form several polyphenols and further enhanced into several flavonoids against the reactive oxygen species (ROS) as the primary defend pathway, in addition, ascorbate, trehalose and nicotinamide also were activated and help decrease the damage from oxidative stress. These results provide insights into the mechanism underlying the phytotoxicity of PFOS. (C) 2018 Elsevier B.V. All rights reserved.

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