数字农科院2.0

Plasma Metabonomics And Proteomics Studies On The Anti-Thrombosis Mechanism Of Aspirin Eugenol Ester In Rat Tail Thrombosis Model

文献类型： 外文期刊

作者： Ma, N; Yang, YJ; Liu, XW; Li, SH; Qin, Z; Li, JY

作者机构：

关键词： Thrombosis; Aspirin Eugenol Ester; Itraq; Omics; Carrageenan

期刊名称： JOURNAL OF PROTEOMICS

ISSN： 1874-3919

年卷期： 2020 年 215 卷

页码：

收录情况： JCR（2021版）

摘要： Aspirin eugenol eater (AEE), a new drug compound, was synthesized through the combination of aspirin and eugenol. Antithrombotic effects of AEE have been confirmed in carrageenan-induced rat tail thrombosis model. However, its mechanism is unclear. With the application of integrated approach combining proteomics and metabolomics, the profilings of protein and metabolite in plasma were examined in thrombosis rat pretreated with AEE, aspirin and eugenol, respectively. A clear separation of the plasma metabolic profiles from different groups was found in score plots. 15 metabolites related with the metabolism of fatty acid, energy and amino acid were found. A total of 144, 38, 41 and 54 differentially abundant proteins (DAPS) were identified in control, AEE, aspirin and eugenol group, respectively. Proteomic results showed that aspirin modulated 7 proteins in amino acid metabolism and 4 proteins in complement system; eugenol regulated the 8 proteins related with coagulation cascades and fibrinogen; AEE improved 3 proteins in TCA cycle and 3 in lipid metabolism. Integrated analysis suggested that AEE improved fatty acid, energy and lipid metabolism to against thrombosis. Results of this study indicated AEE had different action mechanism on thrombosis from aspirin and eugenol, and contribute to understanding the mechanisms of AEE on thrombosis. Significance: Thrombosis is a threat to human health, and there is an urgent need for new drug. In this study, compared with the model group, plasma metabolic profiles in AEE-treated rats were clearly separated; 15 metabolites and 38 proteins were picked out. These metabolites and proteins may assist in understanding the action mechanism of AEE on thrombosis. The results of plasma metabonomics and proteomics also revealed the different action mechanism among AEE, aspirin and eugenol on thrombosis. This study established the foundation to further evaluate the druggability of AEE on thrombosis treatment.

分类号：

  • 相关文献

[1]Feces And Liver Tissue Metabonomics S.tudies On The Regulatory E ffect Of Aspirin Eugenol Eater In Hyperlipidemic Rats. Jiao, Zenghua,Dong Pengcheng,,Kong, Xiaojun,Yang, Yajun,Liu, Xiwang,Ma Ning,Qin, Zhe,Li, Shihong,Li, Jianyong. 2017

[2]Evaluation of texture, retrogradation enthalpy, water mobility, and anti-staling effects of enzymes and hydrocolloids in potato steamed bread. Ma M., Mu T., Sun H., Zhou L.. 2022

[3]Vitamin k in covid-19—potential anti-covid-19 properties of fermented milk fortified with bee honey as a natural source of vitamin k and probiotics. Amira Mohammed Ali,Hiroshi Kunugi,Hend A. Abdelmageed,Ahmed S. Mandour,Mostafa Elsayed Ahmed,Saboor Ahmad,Amin Omar Hendawy. 2021

[4]Multi-Omics Approaches for Liver Reveal the Thromboprophylaxis Mechanism of Aspirin Eugenol Ester in Rat Thrombosis Model. Tao Q.,Ma N.,Fan L.,Ge W.,Zhang Z.,Liu X.,Li J.,Yang Y.. 2024

[5]Platelet Proteomics and Tissue Metabolomics Investigation for the Mechanism of Aspirin Eugenol Ester on Preventive Thrombosis Mechanism in a Rat Thrombosis Model. Qi Tao,Li Ping Fan,Ji Feng,Zhi Jie Zhang,Xi Wang Liu,Zhe Qin,Jian Yong Li,Ya Jun Yang. 2024

[6]Omics Approaches For Engineering Wheat P.roduction Under Abiotic Stresses. Shah, T, Xu, JS, Zou, XL, Cheng, Y, Nasir, M, Zhang, XK. 2018

[7]Phytoremediation Of Cadmium: Physiological, Biochemical, And Molecular Mechanisms. Raza, A, Habib, M, Kakavand, SN, Zahid, Z, Zahra, N, Sharif, R, Hasanuzzaman, M. 2020

[8]Research Progress And Perspective On D.rought Stress In Legumes: A Review. Nadeem, M, Li, JJ, Yahya, M, Sher, A, Ma, CX, Wang, XB, Qiu, LJ. 2019

[9]Integrated Omics Data Of Two A.nnual Ryegrass (Lolium Multiflorum L .) Genotypes Reveals Core Metabolic Processes Under Drought Stress. Pan, L, Meng, C, Wang, JP, Ma, X, Fan, XM, Yang, ZF, Zhou, ML, Zhang, XQ. 2018

[10]Transcriptional And Proteomic Analysis Revealed A. Synergistic Effect Of A flatoxin M1 And Ochratoxin A Mycotoxins On The Intestinal Epithelial Integrity Of Differentiated Human Caco-2 Cells. Gao, YN, Li, SL, Bao, XY, Luo, CC, Yang, HG, Wang, JQ, Zhao, SG, Zheng, N. 2018

[11]Complementary Rna-Sequencing Based Transcriptomics And I.traq Proteomics Reveal The M echanism Of The Alleviation Of Quinclorac Stress By Salicylic Acid In Oryza Sativa Ssp Japonica. Zhou, Weijun,Yang, Chong,Wang, Jian,Mao, Bizeng,Long, Meijuan,Li, Lan,Jin, Xiaoli,Islam, Faisal,Ali, Basharat,Ali, Basharat. 2017

[12]Itraq-Based Protein Profiling Of Peach F.ruit During Ripening And S enescence Under Different Temperatures. An, Xiujuan,Yu, Zhifang,Zheng, Xiaolin,Huan, Chen,Huan, Chen,Yu, Mingliang,Xu, Yin,Ma, Ruijuan. 2019

[13]Comparative Itraq Proteomics Revealed Proteins A.ssociated With Horn Development I n Yak. Bao, Pengjia,Guo, Xian,Ding, Xuezhi,Chu, Min,Li, Mingna,Liang, Chunnian,Wu, Xiaoyun,Yan, Ping. 2018

[14]Proteomic Changes During Mcmv Infection Revealed By Itraq Quantitative Proteomic Analysis In Maize. Hu, Ya,Zhou, Xueping,Zhou, Xueping,Dang, Mingqing,Cheng, Qi,Qian, Yajuan,Wu, Jianxiang. 2020

[15]Proteomic Analysis Of Differences In F.iber Development Between Wild A nd Cultivated Gossypium Hirsutum L.. Su, Junji,Yu, Shuxun,Sun, Huiru,Yu, Shuxun,Qin, Yuan,Hao, Pengbo,Sun, Huiru,Wang, Hantao,Hao, Pengbo,Wei, Hengling,Qin, Yuan. 2017

[16]Itraq-Based Quantitative Proteomics Analysis Of C.old Stress-Induced Mechanisms In G rafted Watermelon Seedlings. Shi, Xianfeng,Shi, Xianfeng,Wang, Xibo,Cheng, Fei,Kong, Qiusheng,Bie, Zhilong,Lu, Junyang,Cao, Haishun,Liang, Huang. 2019

[17]Itraq-Based Quantitative Proteomic Analysis Reveals C.old Responsive Proteins Involved I n Leaf Senescence In Upland Cotton (Gossypium Hirsutum L.). Ma, Qifeng,Zhang, Siping,Wei, Hengling,Tao, Chengcheng,Yu, Shuxun,Zheng, Xuewei,Ma, Qiang,Li, Hongbin,Pang, Chaoyou,Zheng, Xuewei,Fan, Shuli. 2017

[18]Proteomic Analysis Of A Rice M.utant Sd58 Possessing A N ovel D1 Allele Of Heterotrimeric G Protein Alpha Subunit (Rga1) In Salt Stress With A Focus On Ros Scavenging. Huang, Rongfeng,Li, Zhe,Guo, Yan,Gao, Yadi,Huang, Rongfeng,Qin, Hua,Wang, Juan,Wang, Juan,Yu, Yanwen,Peng, Peng,Peng, Peng. 2019

[19]Reveal The Molecular Signatures Of H.epatocellular Carcinoma With Different S izes By Itraq Based Quantitative Proteomics. Liu, Xiaolong,Wang, Yingchao,Wang, Yingchao,Liu, Xiaolong,Liu, Jingfeng,Liu, Jingfeng,Liu, Jingfeng,Zeng, Yongyi,Zeng, Yongyi,Zeng, Yongyi,Xing, Xiaohua,Xia, Jiangbao,Xia, Jiangbao,Xing, Xiaohua,Liang, Dong,Liang, Dong,Liang, Dong,Huang, Yao,Han, Xiao,Huang, Yao,Huang, Yao,Liu, Hongzhi,Liu, Hongzhi,Liu, Hongzhi,Lin, Minjie,Liao, Naishun,Liao, Naishun,Lin, Minjie. 2017

[20]Itraq-Based Quantitative Proteomic Analysis Of M.idgut In Silkworm Infected W ith Bombyx Mori Cytoplasmic Polyhedrosis Virus. Gao, K, Deng, XY, Shang, MK, Qin, GX, Hou, CX, Guo, XJ. 2017

作者其他论文 更多>>