数字农科院2.0

Cross Protection Induced By Combined Subolesin-Based Dna And Protein Immunizations Against Adult Haemaphysalis Longicornis

文献类型： 外文期刊

作者： Hassan, IA; Wang, YN; Zhou, YZ; Cao, J; Zhang, HS; Zhou, JL

作者机构：

关键词： Anti-Tick Vaccine; Subolesin; Ribosomal P0; Dna Vaccine; Chimeric Polypeptide

期刊名称： VACCINE

ISSN： 0264-410X

年卷期： 2020 年 38 卷 4 期

页码：

收录情况： JCR（2021版）

摘要： Vaccination against ticks is an environmentally friendly alternative control method compared to chemical acaricide applications. Subolesin is a conserved protein in ticks, which can provide protection against some tick species. In this study, we evaluated the capacity of cocktail vaccination with Subolesin and ribosomal acidic protein 0 (P0) peptide against adults of Haemaphysalis longicornis. Priming with DNA vaccine expressing subolesin, followed by boosters of a single antigen (rRhSub) or a chimeric polypeptide (rRhSub/P0), provided cross protection. This treatment resulted in significant mortality, reduced blood ingestion and reduced reproduction in H. longicornis adults. Vaccination efficacies of 79.3% and 86.6% are reported in groups supplemented with rRhSub and rRhSub/P0, respectively. Conserved antigens, such as subolesin, formulated as DNA vaccine and enhanced with chimeric polypeptides, could be used as an anti-tick vaccine application, especially for control of infestation involving several tick species. (C) 2019 The Author(s). Published by Elsevier Ltd.

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