数字农科院2.0

Evaluation Of Protective Efficacy Of Inactivated Mycoplasma Synoviae Vaccine With Different Adjuvants

文献类型： 外文期刊

作者： Gong, XW; Chen, QW; Ferguson-Noel, N; Stipkovits, L; Szathmary, S; Liu, YS; Zheng, FY

作者机构：

关键词： Mycoplasma Synoviae; Adjuvants; Subcutaneous Immunization; Bacterin

期刊名称： VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

ISSN： 0165-2427

年卷期： 2020 年 220 卷

页码：

收录情况： JCR（2021版）

摘要： Mycoplasma synoviae (MS) is a poultry pathogen with a reported distribution throughout the world. Vaccination is utilized as an important component of MS control programs for MS infection. The aim of this study was to evaluate protection efficacy of an inactivated MS vaccine (MS bacterin) with different adjuvants in broilers against a Chinese field isolate (CHN-BZJ2-2015). Vaccination with adjuvants ISA 71 VG and chitosan, respectively, enhanced specific lymphocyte proliferation responses and upregulated the expression of IL-1 beta, IL-6, IL-2 and IFN-gamma prior to challenge. Furthermore, vaccination with adjuvant ISA 71 VG elicited the highest antibody titers, exhibited significantly lower air sac, foot pad and tracheal lesions than the other groups (P < 0.05), and decreased MS colonization. These results demonstrated that inactivated MS vaccine with ISA 71 VG is able to induce both cellular and humoral immune response in broilers and confers a high level of protection upon challenge, demonstrating a potential application in the field.

分类号：

  • 相关文献

[1]Ultrasonic Assisted Extraction Of Paclitaxel F.rom Taxus X Media U sing Ionic Liquids As Adjuvants: Optimization Of The Process By Response Surface Methodology. Tan, ZJ, Li, Q, Wang, CY, Zhou, WL, Yang, YR, Wang, HY, Yi, YJ, Li, FF. 2017

[2]Deep Eutectic Solvents Used As A.djuvants For Improving The S alting-Out Extraction Of Ursolic Acid From Cynomorium Songaricum Rupr. In Aqueous Two-Phase System. Cai, CY, Wu, SG, Wang, CY, Yang, YR, Sun, DY, Li, FF, Tan, ZJ. 2019

[3]Mucosal Vaccines: Strategies And Challenges. Li, M, Wang, Y, Sun, Y, Cui, HY, Zhu, SJ, Qiu, HJ. 2020

[4]Mycoplasma synoviae enolase is a plasminogen/fibronectin binding protein. Bao, Shijun,Yu, Shengqing,Tan, Lei,Zhang, Fanqin,Sun, Yingjie,Qiu, Xusheng,Ding, Chan,Bao, Shijun,Guo, Xiaoqin,Ding, Jiabo,Chen, Guanghua. 2014

[5]NADH oxidase of Mycoplasma synoviae is a potential diagnostic antigen, plasminogen/fibronectin binding protein and a putative adhesin. Hu Z.,Li H.,Zhao Y.,Wang G.,Shang Y.,Chen Y.,Wang S.,Tian M.,Qi J.,Yu S.. 2022

[6]Development of an indirect ELISA based on a new specific lipoprotein LP53 for the detection of antibodies against Mycoplasma synoviae. Haoran Li,Zengjin Hu,Guijun Wang,Yu Wang,Shaohui Wang,Mingxing Tian,Yanqing Bao,Jingjing Qi,Shengqing Yu. 2025

[7]The quadruplex fluorescent quantitative PCR method for the simultaneous detection of respiratory diseases in quail: Pasteurella multocida, Avibacterium paragallinarum, Mycoplasma gallisepticum, and Mycoplasma synoviae. Wang, Haojie,Xue, Lihong,Wang, Longxi,Liu, Yixuan,Chen, Jianxing,Sun, Yue,An, Tongqing,Li, Changwen,Chen, Hongyan,Yu, Changqing,Xia, Changyou,Zhang, He. 2025

[8]Using a novel gene site to develop a duplex real-time TaqMan MGB probe PCR method for the SNP detection and differentiation between the MS-H live vaccine strain and wild-type Mycoplasma synoviae strains. Luru Zhao,Xiaochuan Tang,Weiqi Guo,Bin Zhang,Haoheng Peng,Lijun Ye,Yinan Liu,Jingyi Liang,Mingxing Tian,Yanqing Bao,Jingjing Qi,Shaohui Wang. 2025

作者其他论文 更多>>