数字农科院2.0

Mimicking Neuromelanin Nanoparticles As A Selective Pb2+ Probe

文献类型： 外文期刊

作者： Zhang, S; Xiao, M; Zhang, YQ; Li, Y; Liu, H; Han, G; Rathi, B; Lyu, KY; Wu, LD

作者机构：

关键词： Neuromelanin-Like Nanoparticles; Amino Acid; Fluorescence; Lead Ions

期刊名称： ANALYTICA CHIMICA ACTA

ISSN： 0003-2670

年卷期： 2020 年 1105 卷

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： Exposure to even very low concentration of Pb2+ can cause neurological and developmental disorders, and affects children more severely. Neuromelanin (NM) in the substantial nigra can trap endogenous and environmental toxins and immobilize them as stable adducts, thus protecting brain against toxicity. Until now, the structure and Pb2+-chelating ability of NM is still little understood. Here, we prepare a mimicking NM by amino acid and dopamine. The prepared NM has strong fluorescent and its fluorescence can be quenched by Pb2+. This study offers a novel way to synthetic NM and provides an effective method to detect Pb2+. (C) 2020 Elsevier B.V. All rights reserved.

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