数字农科院2.0

Cuas: A Database Of Annotated Transcripts Generated By Alternative Splicing In Cucumbers

文献类型： 外文期刊

作者： Sun, Y; Zhang, QB; Liu, B; Lin, K; Zhang, ZH; Pang, EL

作者机构：

关键词： Cucumber; Alternative Splicing; Isoform-Level Function; Isoform-Level Features; Tissue-Specific Alternative Splicing Events

期刊名称： BMC PLANT BIOLOGY

ISSN： 1471-2229

年卷期： 2020 年 20 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： Background Alternative splicing (AS) plays a critical regulatory role in modulating transcriptome and proteome diversity. In particular, it increases the functional diversity of proteins. Recent genome-wide analysis of AS using RNA-Seq has revealed that AS is highly pervasive in plants. Furthermore, it has been suggested that most AS events are subject to tissue-specific regulation. Description To reveal the functional characteristics induced by AS and tissue-specific splicing events, a database for exploring these characteristics is needed, especially in plants. To address these goals, we constructed a database of annotated transcripts generated by alternative splicing in cucumbers (CuAS: ) that integrates genomic annotations, isoform-level functions, isoform-level features, and tissue-specific AS events among multiple tissues. CuAS supports a retrieval system that identifies unique IDs (gene ID, isoform ID, UniProt ID, and gene name), chromosomal positions, and gene families, and a browser for visualization of each gene. Conclusion We believe that CuAS could be helpful for revealing the novel functional characteristics induced by AS and tissue-specific AS events in cucumbers. CuAS is freely available at http://cmb.bnu.edu.cn/alt_iso/index.php.

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