数字农科院2.0

Effect Of Duck Hepatitis A Virus Genotype 3 Infection On Glucose Metabolism Of Pekin Ducklings And Underlying Mechanism

文献类型： 外文期刊

作者： Liang, SY; Tang, J; Wang, XY; Wen, ZG; Xie, M; Wu, YB; Hou, SS; Zhang, DB

作者机构：

关键词： Dhav-3; Metabolism; Glucose; Aspartate Aminotransferase

期刊名称： GENE

ISSN： 0378-1119

年卷期： 2020 年 748 卷

页码：

收录情况： JCR（2021版）

摘要： Earlier works identified the second generation (Z8R2) of a resistant Pekin duck line to duck hepatitis A virus genotype 3 (DHAV-3), which displays significantly strong resistance than that of the second generation (Z8S2) of a susceptible Pekin duck line. To understand the genetic mechanisms that determine the different resistance/susceptibility of Z8R2 and Z8S2 to DHAV-3, transcriptome analysis on livers of infected Pekin ducklings was performed to screen differentially expressed genes (DEGs). We found that DHAV-3 infection has a great effect on metabolism of Z8S2 at the transcription level. Using a newly created fourth generation of the resistant Pekin duck line (Z8R4) and an unselected Pekin duck flock (Z7) as models, hypoglycemia and dramatically increased aspartate aminotransferase and alanine aminotransferase were shown to be noticeable signs of fatal cases caused by DHAV-3 infection. These findings, together with expression analysis and verification of DEGs, support the view that DHAV-3 infection results in glucose metabolic abnormalities in susceptible individuals and that there are significant differences in expression patterns of glucose metabolism-related DEGs between susceptible and resistant individuals. Notably, cytokines displayed a negative correlation with glucose synthesis in terms of expression in susceptible individuals following DHAV-3 infection. Mechanism analyses suggests that cytokines will activate PI3K-AKT pathway and/or JAK-STAT pathway by up-regulated expression of JAK2, and thereby causes down-regulated expression of G6PC and/or ACAT1. Cytokines can also cause down-regulated expression of HPGDS by JAK2. The present work contributes to the understanding of pathogenesis of DHAV-3 infection and the resistance breeding project against DHAV-3.

分类号：

  • 相关文献

[1]Quantitative proteomics reveals tissue-specific toxic mechanisms for acute hydrogen sulfide-induced injury of diverse organs in pig. Liu Z., Chen L., Gao X., Zou R., Meng Q., Fu Q., Xie Y., Miao Q., Chen L., Tang X., Zhang S., Zhang H., Schroyen M.. 2022

[2]易感和抗性北京鸭感染DHAV-3后血浆生化指标的动态变化研究. 胡迪,梁锐萍,王霞,曹俊婷,邢光楠,王帅钦,侯水生,张云生. 2024

[3]DHAV-3感染对不同日龄雏鸭胆汁分泌通路的影响. 鲁美希,李慧慧,唐熠,梁素芸,侯水生. 2025

[4]Hydroxylamine And Carboxymethoxylamine Can Inhibit Toxoplasma Gondii Growth Through An Aspartate Aminotransferase-Independent Pathway. Li, JX, Guo, HP, Galon, EM, Gao, Y, Lee, SH, Liu, MM, Li, YC, Ji, SW, Jia, HL, Xuan, XN. 2020

[5]NOD1 Is Associated With the Susceptibility of Pekin Duck Flock to Duck Hepatitis A Virus Genotype 3. Suyun Liang,Ming Shan Wang,Bo Zhang,Yulong Feng,Jing Tang,Ming Xie,Wei Huang,Qi Zhang,Dabing Zhang,Shuisheng Hou. 2021

[6]Plasma lipidome reveals susceptibility and resistance of Pekin ducks to DHAV-3. Xia Wang,Dingbang Ding,Ying Liu,Haonan Zhao,Jianfeng Sun,Yang Li,Junting Cao,Shuisheng Hou,Yunsheng Zhang. 2023

[7]Genomic Landscape and Regulation of RNA Editing in Pekin Ducks Susceptible to Duck Hepatitis A Virus Genotype 3 Infection. Zhao, Haonao,Wu, Zifang,Wang, Zezhong,Ru, Jinlong,Wang, Shuaiqin,Li, Yang,Hou, Shuisheng,Zhang, Yunsheng,Wang, Xia. 2024

[8]Effects of age on differential resistance to duck hepatitis A virus genotype 3 in Pekin ducks by 16 S and transcriptomics. Liang S.,Lu M.,Yu D.,Xing G.,Ji Z.,Guo Z.,Zhang Q.,Huang W.,Xie M.,Hou S.. 2024

[9]Effects of DHAV-3 infection on innate immunity, antioxidant capacity, and lipid metabolism in ducks with different DHAV-3 susceptibilities. Cao J.,Wen Z.,Zhang Y.,Zhang B.,Chen Y.,Xing G.,Wu Y.,Zhou Z.,Liu X.,Hou S.. 2024

[10]Whole-transcriptome sequencing revealed the role of noncoding RNAs in susceptibility and resistance of Pekin ducks to DHAV-3. Dingbang Ding,Haonan Zhao,Ying Liu,Shaofei Li,Jie Wei,Yuze Yang,Shuaiqin Wang,Guangnan Xing,Shuisheng Hou,Xia Wang,Yunsheng Zhang. 2024

[11]Single-cell RNA sequencing reveals intrahepatic signature related to pathobiology of duck hepatitis A virus type 3 (DHAV-3) infection. Yunsheng Zhang,Dingbang Ding,Shaofei Li,Qiong Pan,Jinlong Ru,Haonan Zhao,Guang Yao,Jie Wei,Shuaiqin Wang,Shuisheng Hou,Xia Wang. 2025

[12]Host lipid metabolism influences the variation in resistance of Pekin ducks to duck hepatitis A virus genotype 3. Suyun Liang,Zhuo Chang,Meixi Lu,Zhanbao Guo,Dawei Luo,Guangnan Xing,Ming Xie,Wei Huang,Shuisheng Hou. 2025

[13]Early antioxidant capacity, intestinal barrier integrity and gut microbiota drive DHAV-3 resistance in ducks. Cao, Junting,Xu, Tong,Wu, Yongbao,Wang, Qimeng,Zhang, Bo,Yang, Yiwen,Guo, Yanhong,Zhang, Yunsheng,Zhou, Zhengkui,Hou, Shuisheng,Wen, Zhiguo. 2026

[14]Decoding the B-cell immune landscape in duck hepatitis A virus type 3 through single-cell genomics. Saisai Zhao,Yaru Fan,Dalin He,Mian Wu,Xinyuan Xu,Xinhong Man,Siming Zhu,Ruiqi Shi,Yafei Qin,Hong Yu Ma,Qiang Feng,Yi Tang,Youxiang Diao. 2025

[15]Polymorphisms of FUT9 and its relationship with susceptibility towards DHAV-3 in Pekin duck. Junting Cao,Jian Hu,Bo Zhang,Yunsheng Zhang,Zhiguo Wen,Yongbao Wu,Zhigang Hu,Zhengkui Zhou,Xiaolin Liu,Shuisheng Hou. 2025

[16]Global dissemination and evolutionary dynamics of duck hepatitis A virus type 3 driven by VP1 gene variation. Zhao, Saisai,Hao, Yizhang,Zhang, Qing,Li, Bing,Fan, Yaru,Liu, Guocheng,Li, Yiman,Zhang, Jiahao,Tang, Yi,Diao, Youxiang. 2025

[17]Stage-specific antiviral roles of IFIH1, IRF7, and MAVS in the interferon-mediated response to DHAV-3 infection. Huihui Li,Yi Tang,Shuisheng Hou,Suyun Liang. 2025

[18]Circular RNA circPTPN3 facilitates duck hepatitis A virus type 3 (DHAV-3) infection by reducing miR-130b-5p function in duck. Ying Liu,Shaofei Li,Xiang Mei,Shujie Tian,Junting Cao,Shuaiqin Wang,Shuisheng Hou,Xia Wang,Yunsheng Zhang. 2025

[19]Mechanochemical-Assisted Hydrolysis Of Pretreated Rice S.traw Into Glucose And X ylose In Water By Weakly Acidic Solid Catalyst. Qiu, Mo,Shen, Feng,Yan, Lulu,Qi, Xinhua,Qi, Xinhua. 2019

[20]Efficient Hydrolysis Of Cellulose To G.lucose In Water By A gricultural Residue-Derived Solid Acid Catalyst. Su, JL, Qiu, M, Shen, F, Qi, XH. 2018

作者其他论文 更多>>