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Vitamin B and Vitamin C affect DNA methylation and amino acid metabolism in Mycobacterium bovis BCG

文献类型： 外文期刊

作者： Song, Ningning;Zhu, Yongqiang;Cui, Yingying;Zheng, Huajun;Lv, Mingyue;Tang, Yiyi;Cui, Ziyin;Dang, Guanghui;Liu, Siguo

作者机构：

关键词： Vitamin; Methylation; Amino Acid; Mycobacterium; Cysterine Synthase A

期刊名称： Frontiers in Microbiology

ISSN： 1664-302X

年卷期： 2020 年 11 卷

页码：

收录情况： JCR（2021版）

摘要： Vitamins are essential nutrients and key cofactors of enzymes that regulate cellular metabolism, and also activate the immune system. Recent studies have shown that vitamin B1 (V-B(1)) and vitamin C (Vc) can inhibit Mycobacterium tuberculosis growth, but the precise mechanism is still not well understood. In the present study, we have used RNA-sequencing (RNA-seq), liquid chromatography coupled to mass spectrometry (LC-MS) and single-molecule real-time (SMRT) sequencing to analyze the transcriptional, metabolic and methylation profiles of Mycobacterium bovis BCG when treated with V-B(1) and Vc. Our results show that, after vitamin treatment, variant metabolites were mainly clustered in pathways related to amino acid metabolism. Treatment with both vitamins significantly up-regulated the gene encoding cysteine synthase A. Additionally, only BCG that was treated with V-C showed m4c modifications. Genes harboring this methylation were up-regulated, suggesting that m4c methylation can promote gene transcription to some extent. Overall, this study contributes to the understanding of the effects of V-B(1) and V-C, and suggests that these vitamins constitute potential anti-tuberculosis drugs.

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