数字农科院2.0

Organic Selenium Supplement Partially Alleviated Diquat-Induced Oxidative Insults And Hepatic Metabolic Stress In Nursery Pigs

文献类型： 外文期刊

作者： Doan, N; Liu, YH; Xiong, X; Kim, K; Wu, ZH; Bravo, DM; Blanchard, A; Ji, P

作者机构：

关键词： Selenium Sources; Diquat Challenge; Oxidative Stress; Nursery Pigs; Hepatic Metabolomics

期刊名称： BRITISH JOURNAL OF NUTRITION

ISSN： 0007-1145

年卷期： 2020 年 124 卷 1 期

页码：

收录情况： JCR（2021版）

摘要： The study investigated antioxidant effects of Se on resilience to diquat-induced oxidative stress in nursery pigs. Thirty-five weaned pigs were individually housed and randomly assigned to one of the five treatments. Pigs were (1) fed a basal diet and intraperitoneally injected with sterile saline (negative control), (2) fed the basal diet and injected with diquat solution (positive control, PC), or fed the basal diet supplemented with 0 center dot 3 mg Se/kg as (3) sodium selenite (SS), (4) soyabean protein-chelated Se (SC) or (5) selenised yeast (SY) and intraperitoneally injected with diquat. Pigs were fed the experimental diets for 17 d and injected with diquat at 10 mg/kg body weight or saline on the 11th day of the study (day 0 post-injection (PI)). Diquat exposure induced acute stress and innate immune activation (P< 0 center dot 05) at 6 h PI and compromised (P< 0 center dot 05) plasma glutathione peroxidase activity on day 2 PI, which was accompanied by an increase in plasma malondialdehyde at 6 h and day 2 PI (P< 0 center dot 10). Organic Se, particularly SY, enhanced (P< 0 center dot 05) endogenous antioxidant activity in various aspects compared with the PC group. The growth rate and feed intake from day 0 to day 7 PI were significantly lower in the PC, SS and SC groups than the NC group (P< 0 center dot 05). Untargeted metabolomics analysis revealed that twenty-two hepatic metabolites (false discovery rate < 0 center dot 15) associated with lipid and cellular antioxidant metabolism were altered by diquat. SY restored hepatic metabolic profiles in some but not all samples.

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