数字农科院2.0

Evolutionary Relationship And Population Structure Of Domestic Bovidae Animals Based On Mhc-Linked And Neutral Autosomal Microsatellite Markers

文献类型： 外文期刊

作者： Guang-Xin, E; Chen, LP; Zhou, DK; Yang, BG; Zhang, JH; Zhao, YJ; Hong, QH; Ma, YH; Chu, MX; Zhang, LP; Basang, WD; Zhu, YB; Han, YG; Na, RS; Zeng, Y; Zhao, ZQ; Huang, YF; Han, JL

作者机构：

关键词： Major Histocompatibility Complex; Interspecific Polymorphism; Diversity; Heterozygote Advantage

期刊名称： MOLECULAR IMMUNOLOGY

ISSN： 0161-5890

年卷期： 2020 年 124 卷

页码：

收录情况： JCR（2021版）

摘要： Major histocompatibility complex (MHC) genes are critical for disease resistance or susceptibility responsible for host-pathogen interactions determined mainly by extensive polymorphisms in the MHC genes. Here, we examined the diversity and phylogenetic pattern of MHC haplotypes reconstructed using three MHC-linked microsatellite markers in 55 populations of five Bovidae species and compared them with those based on neutral autosomal microsatellite markers (NAMs). Three-hundred-and-forty MHC haplotypes were identified in 1453 Bovidae individuals, suggesting significantly higher polymorphism and heterozygosity compared with those based on NAMs. The ambitious boundaries in population differentiation (phylogenetic network, pairwise F-ST and STRUCTURE analyses) within and between species assessed using the MHC haplotypes were different from those revealed by NAMs associated closely with speciation, geographical distribution, domestication and management histories. In addition, the mean FST was significantly correlated negatively with the number of observed alleles (N-A), observed (H-O) and expected (H-E) heterozygosity and polymorphism information content (PIC) (P< 0.05) in the MHC haplotype dataset while there was no correction of the mean FST estimates (P> 0.05) between the MHC haplotype and NAMs datasets. Analysis of molecular variance (AMOVA) revealed a lower percentage of total variance (PTV) between species/groups based on the MHC-linked microsatellites than NAMs. Therefore, it was inferred that individuals within populations accumulated as many MHC variants as possible to increase their heterozygosity and thus the survival rate of their affiliated populations and species, which eventually reduced population differentiation and thereby complicated their classification and phylogenetic relationship inference. In summary, host-pathogen coevolution and heterozygote advantage, rather than demographic history, act as key driving forces shaping the MHC diversity within the populations and determining the interspecific MHC diversity.

分类号：

  • 相关文献

[1]Swine Leukocyte Antigen Diversity In C.anadian Specific Pathogen-Free Yorkshire A nd Landrace Pigs. Gao, CX, Quan, JQ, Jiang, XJ, Li, CW, Lu, XY, Chen, HY. 2017

[2]Molecular Genetic Characterization And Haplotype D.iversity Of Swine Leukocyte A ntigen In Chinese Rongshui Miniature Pigs. Gao, CX, Xin, C, Wang, XY, Quan, JQ, Li, CW, Wang, JY, Chen, HY. 2019

[3]利用但基因组扩增法对马传染性贫血病毒疫苗株异质性的分析. 韦华冕,王雪峰,王珊珊,杜承,刘海芳,刘强,周建华. 2012

[4]Transposable Element-Mediated Balancing Selection At H.sp90 Underlies Embryo Developmental V ariation. Chen, B, Zhang, B, Xu, LL, Li, Q, Jiang, F, Yang, PC, Xu, YA, Kang, L. 2017

[5]Expression profiles of genes within a subregion of chicken major histocompatibility complex B in spleen after Marek's disease virus infection. Lian, L.,Qu, L. J.,Zheng, J. X.,Chen, Y. M.,Xu, G. Y.,Yang, N.,Liu, C. J.,Zhang, Y. P.. 2010

[6]Molecular characterization of swine leukocyte antigen class I genes by sequence-based and PCR-SSP method in Guizhou minipigs. Xia, Jihan,Liu, Zizhan,Xin, Leilei,Yang, Shulin,Li, Kui,Wang, Zaigui,Qian, Lin,Wu, Shuguang.

[7]Low diversity of the major histocompatibility complex class II DRA gene in domestic goats (Capra hircus) in Southern China. Chen, L. P.,E, G. X.,Zhao, Y. J.,Na, R. S.,Zhao, Z. Q.,Zhang, J. H.,Sun, Y. W.,Huang, Y. F.,Ma, Y. H.,Zhong, T.,Zhang, H. P.. 2015

[8]Genetic variability, evidence of potential recombinational event and selection of LEI0258 in chicken. E, Guangxin,Sha, Rinai,Zeng, Shengcheng,Wang, Chen,Han, Jianlin,Pan, Jianfei.

[9]Characterization of swine leukocyte antigen (SLA) polymorphism by sequence-based and PCR-SSP methods in Chinese Bama miniature pigs. Gao, Caixia,Jiang, Qian,Guo, Dongchun,Liu, Jiasen,Han, Lingxia,Qu, Liandong.

[10]Identification Of Two Novel Foot-And-Mouth D.isease Virus Cytotoxic T L ymphocyte Epitopes That Can Bind Six Sla-I Proteins. Gao, FS, Zhai, XX, Jiang, P, Zhang, Q, Gao, H, Li, ZB, Han, Y, Yang, J, Zhang, ZH. 2018

[11]Molecular Cloning And Bioinformatics Analysis O.f Dqa Gene From M ink (Neovison Vison). Fan, ZB, Zhang, HF, Rong, M, Meng, DM, Yu, ZX, Jiang, LL, Jiang, PH. 2019

[12]N-Fertilizer-Driven Association Between The Arbuscular M.ycorrhizal Fungal Community And D iazotrophic Community Impacts Wheat Yield. Tian, Guangli,Luo, Gongwen,Wang, Min,Tian, Guangli,Shen, Qirong,Kong, Yali,Zhu, Chen,Ling, Ning,Guo, Shiwei,Guo, Junjie. 2018

[13]Effect Of Fumigation With Chloropicrin O.n Soil Bacterial Communities A nd Genes Encoding Key Enzymes Involved In Nitrogen Cycling. Guo, Meixia,Cao, Aocheng,Yan, Dongdong,Yan, Dongdong,Wang, Qiuxia,Li, Yuan,Wang, Qiuxia,Guo, Meixia,Fang, Wensheng,Cao, Aocheng,Li, Yuan,Li, Jun,Huang, Bin. 2017

[14]Diversity Of Copy Number Variation I.n A Worldwide Population O f Sheep. Yang, L, Xu, LY, Zhou, Y, Liu, M, Wang, L, Kijas, JW, Zhang, HP, Li, L, Liu, GE. 2018

[15]High-Throughput Sequencing Reveals Bacterial Community C.omposition In The Rhizosphere O f The Invasive Plant Flaveria Bidentis. Song, Z, Zhang, RH, Fu, WD, Zhang, T, Yan, J, Zhang, GL. 2017

[16]Characterization And Pathogenicity Of Fusarium Species Associated With Soybean Pods In Maize/Soybean Strip Intercropping. Liu, Taiguo,Fahim Abbas, Muhammad,Chen, Wanquan,Irshad, Gulshan,Chang, Xiaoli,Yan, Li,Raza, Muhammad Ali,Naeem, Muhammd,Li, Hongju,Gong, Guoshu,Zhang, Min,Shang, Jing,Chen, Huabao,Yang, Chunping,Chang, Xiaoli,Ibrahim Khaskheli, Muhammad,Yang, Wenyu. 2019

[17]Effects Of Fertilizations On Soil B.acteria And Fungi Communities I n A Degraded Arid Steppe Revealed By High Through-Put Sequencing. Yao, LH, Wang, DJ, Kang, L, Wang, DK, Zhang, Y, Hou, XY, Guo, YJ. 2018

[18]Illumina-Based Analysis Of Endophytic And R.hizosphere Bacterial Diversity Of T he Coastal Halophyte &Itmesserschmidia Sibirica&It. Tian, XY, Zhang, CS. 2017

[19]Secondary Crops And Non-Crop Habitats W.ithin Landscapes Enhance The A bundance And Diversity Of Generalist Predators. Liu, Bing,Lu, Yanhui,Yang, Fan,Yang, Long,Yang, Yizhong,Zeng, Yingda,Liu, Bing. 2018

[20]Different Substrate Regimes Determine Transcriptional P.rofiles And Gene Co-Expression I n Methanosarcina Barkeri (Dsm 800). Lin, Q, Fang, XY, Ho, A, Li, JY, Yan, XF, Tu, B, Li, CN, Li, JB, Yao, MJ, Li, XZ. 2017

作者其他论文 更多>>