数字农科院2.0

Argonaute Proteins: Structural Features, Functions And Emerging Roles

文献类型： 外文期刊

作者： Wu, JE; Yang, J; Cho, WC; Zheng, YD

作者机构：

关键词： Argonaute Protein; Small Rna; Mirnas; Pirnas; Post-Translational Modification

期刊名称： JOURNAL OF ADVANCED RESEARCH

ISSN： 2090-1232

年卷期： 2020 年 24 卷

页码：

收录情况： JCR（2021版）

摘要： Argonaute proteins are highly conserved in almost all organisms. They not only involve in the biogenesis of small regulatory RNAs, but also regulate gene expression and defend against foreign pathogen invasion via small RNA-mediated gene silencing pathways. As a key player in these pathways, the abnormal expression and/or mis-modifications of Argonaute proteins lead to the disorder of small RNA biogenesis and functions, thus influencing multiply biological processes and disease development, especially cancer. In this review, we focus on the post-translational modifications and novel functions of Argonaute proteins in alternative splicing, host defense and genome editing. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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