数字农科院2.0

Bcrpd3-Mediated Histone Deacetylation Is Involved In Growth And Pathogenicity Ofbotrytis Cinerea

文献类型： 外文期刊

作者： Zhang, N; Yang, ZZ; Zhang, ZH; Liang, WX

作者机构：

关键词： Botrytis Cinerea; Histone Acetylation; Deacetylase; Pathogenicity; Rna-Seq

期刊名称： FRONTIERS IN MICROBIOLOGY

ISSN： 1664-302X

年卷期： 2020 年 11 卷

页码：

收录情况： JCR（2021版）

摘要： Histone deacetylase activity plays an important role in transcriptional repression.Botrytis cinereais an important necrotrophic fungal pathogen distributed worldwide and parasites a wide range of hosts. However, the molecular mechanisms of howB. cinerearegulates growth and host infection remain largely unknown. Here, the function of BcRPD3, a histone deacetylase ofB. cinerea, was investigated. Overexpression of theBcRPD3gene resulted in significantly decreased acetylation levels of histone H3 and H4. TheBcRPD3overexpression strains showed slightly delayed vegetative growth, dramatically impaired infection structure formation, oxidative stress response, and virulence. RNA-Seq analysis revealed that enzymatic activity related genes, including 9 genes reported to function as virulence factors, were downregulated inBcRPD3overexpression strain. Chromatin immunoprecipitation followed by qPCR confirmed the enrichment of BcRPD3 and H3Kac at the promoter regions of these nine genes. These observations indicated that BcRPD3 regulated the transcription of enzymatic activity related genes by controlling the acetylation level of histones, thereby affecting the vegetative growth, infection structure formation, oxidative stress response, and virulence ofB. cinerea.

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