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Differential expression of immune-related cytokine genes in response to J group avian leukosis virus infection in vivo

文献类型： 外文期刊

作者： Gao, Yanni;Liu, Yongzhen;Guan, Xiaolu;Li, Xiaofei;Yun, Bingling;Qi, Xiaole;Wang, Yongqiang;Gao, Honglei;Cui, Hongyu;Liu, Changjun;Zhang, Yanping;Wang, Xiaomei;Gao, Yulong;Wang, Xiaomei

作者机构：

关键词： ALV-J;Interleukin;Interferon;Innate immune responses

期刊名称： MOLECULAR IMMUNOLOGY

ISSN：

年卷期：

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收录情况： SCI

摘要： Infection with J group avian leukosis virus (ALV-J) can result in immunosuppression and subsequently increased susceptibility to secondary infection. The innate immune system is the first line defense system in prevention of further bacterial and viral infections. Cytokines play key roles in the innate immune system. In this study, we used RT-qPCR technology to test the cytokine mRNA expression levels in various immune tissues, including the spleen, bursa of fabricius and cecal tonsil, in the days following ALV-J infection. The results indicated that in the infected group, the expression levels of interleukin-6 (IL-6), IL-18, interferon-alpha (IFN-alpha) and IFN-gamma significantly increased in the spleen and reached peak levels that were thousandfolds higher than baselines at 9-12 days post-infection (d.p.i.). The levels in the bursa of fabricius slightly increased, and the levels in the cecal tonsil were not significantly altered. Moreover, the pattern of the expression of these three cytokines in the spleens of the infected group was similar to the pattern of viremia of this group. These results suggest that the spleen plays an important role in the interaction between ALV-J infection and the innate immune system. This study contributes to the understanding of innate immune responses to ALV-J infection and also elucidates the mechanisms of the pathogenicity of ALV-J in chickens. (C) 2014 Elsevier Ltd. All rights reserved.

分类号： R392

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