数字农科院2.0

Dendritic cell targeted vaccines: Recent progresses and challenges

文献类型： 外文期刊

作者： Chen, Pengfei;Liu, Xinsheng;Sun, Yuefeng;Zhou, Peng;Wang, Yonglu;Zhang, Yongguang

作者机构：

关键词： cellular immunity;Dendritic cells;humoral immunity;target;vaccine

期刊名称： HUMAN VACCINES & IMMUNOTHERAPEUTICS

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收录情况： SCI

摘要： Dendritic cells (DCs) are known to be a set of morphology, structure and function of heterogeneous professional antigen presenting cells (APCs), as well as the strongest functional antigen presenting cells, which can absorb, process and present antigens. As the key regulators of innate and adaptive immune responses, DCs are at the center of the immune system and capable of interacting with both B cells and T cells, thereby manipulating the humoral and cellular immune responses. DCs provide an essential link between the innate and adaptive immunity, and the strong immune activation function of DCs and their properties of natural adjuvants, make them a valuable target for antigen delivery. Targeting antigens to DC-specific endocytic receptors in combination with the relevant antibodies or ligands along with immunostimulatory adjuvants has been recently recognized as a promising strategy for designing an effective vaccine that elicits a strong and durable T cell response against intracellular pathogens and cancer. This opinion article provides a brief summary of the rationales, superiorities and challenges of existing DC-targeting approaches.

分类号： R392

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