数字农科院2.0

Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-beta Signaling Pathways by Targeting VISA

文献类型： 外文期刊

作者： Wang, Junyong;Ji, Yanhong;Peng, Qianqian;Zeng, Yan;Jia, Yane;Zhu, Qiyun;Lei, Cao-Qi;Ren, Yujie;Zhong, Bo;Shu, Hong-Bing;Zhou, Hongbo;Ge, Jinying;Li, Yu;Wei, Jianzhong

作者机构：

期刊名称： JOURNAL OF IMMUNOLOGY

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Duck Tembusu virus (DTMUV) is an emergent infectious pathogen that has caused severe disease in ducks and huge economic losses to the poultry industry in China since 2009. Previously, we showed that DTMUV inhibits IFN-beta induction early in infection; however, the mechanisms of the inhibition of innate immune responses remain poorly understood. In this study, we screened DTMUV-encoded structural and nonstructural proteins using reporter assays and found that DTMUV NS1 markedly suppressed virus-triggered IFN-beta expression by inhibiting retinoic acid-inducible gene I-like receptor signaling. Moreover, we found that DTMUV NS1 specifically interacted with the C-terminal domain of virus-induced signaling adaptor and impaired the association of retinoic acid-inducible gene I or melanoma differentiation-associated gene 5 and virus-induced signaling adaptor, thereby downregulating the retinoic acid-inducible gene I-like receptor-mediated signal transduction and cellular antiviral responses, leading to evasion of the innate immune response. Together, our findings reveal a novel mechanism manipulated by DTMUV to circumvent the host antiviral immune response.

分类号： Q352

  • 相关文献
作者其他论文 更多>>