数字农科院2.0

Detecting signatures of selection within the Tibetan sheep mitochondrial genome

文献类型： 外文期刊

作者： Niu, Lili;Xiao, Ping;Zhou, Jingxuan;Hu, Jiangtao;Guo, Jiazhong;Li, Li;Wang, Linjie;Zhang, Hongping;Zhong, Tao;Chen, Xiaoyong;Sun, Hongxin;Zhao, Qianjun

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关键词： Copy number;high altitude;mitochondrial Deselection signature;Tibetan sheep

期刊名称： MITOCHONDRIAL DNA PART A

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收录情况： SCI

摘要： Tibetan sheep, a Chinese indigenous breed, are mainly distributed in plateau and mountain-valley areas at a terrestrial elevation between 2260 and 4100 m. The herd is genetically distinct from the other domestic sheep and undergoes acclimatization toadapt to the hypoxic environment. To date, whether the mitochondrial DNA modification of Tibetan sheep shares the same feature as the other domestic breed remains unknown. In this study, we compared the whole mitogenome sequences from 32 Tibetan sheep, 22 domestic sheep and 24 commercial sheep to identify the selection signatures of hypoxic-toler-ant in Tibetan sheep. Nucleotide diversity analysis using the sliding window method showed that the highest level of nucleotide diversity was observed in the control region with a peak value of 7t = 0.05215, while the lowest n value was detected in the tRNAs region. qPCR results showed that the relative mtDNA copy number in Tibetan sheep was significantly lower than that in Suffolk sheep. None of the mutationsin 72S rRNA were fixed in Tibetan sheep, which indicated that there has been less artificial selection in this herd than the other domestic and commercial breeds. Although one site (1277G) might undergo the purifying selection, it was not identified asthe breed-specific allele in Tibetan sheep. We proposed that nature selection was the main drive during the domestication of Tibetan sheep and single mutation (or locus) could not reveal the signature of selection as for the high diversity in the mitogenome of Tibetan sheep.

分类号： Q7

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