数字农科院2.0

Production of avermectins by Streptomyces avermitilis through solid-state fermentation using agro-industrial waste

文献类型： 外文期刊

作者： Guozhong Du;Zhuoxu Dong;Zhengduo Wang;Minghui Pan;Yanyan Zhang;Wensheng Xiang;Shanshan Li

作者机构：

关键词： Agro-industrial waste;Avermectins;Natural products;Solid-state fermentation;Streptomyces;Streptomyces avermitilis

期刊名称： Bioresource Technology

ISSN： 0960-8524

年卷期： 2025 年 431 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The natural products (NPs) avermectins from Streptomyces show exceptional insecticidal activity and become the most widely produced and used biopesticides in the world. Avermectins are produced by submerged fermentation (SmF), generating significant amount of effluent, exhaust gas and solid waste. We therefore endeavored to establish a green and sustainable alternative through solid-state fermentation (SSF) using agro-industrial waste. We determined the optimal culture medium composition and fermentation style through SSF. The maximum concentration of avermectin B1a (3.83 mg/gds) was obtained with a substrate mixture containing wheat bran, corn cob, earthworm cast, sugarcane bagasse, cane molasses, ammonium sulfate and CoCl2 in shallow trays cultivated for 14 days at 28 °C by repeated-batch SSF, and the initial moisture content and inoculum size was set as 78.5 % and 25 %, respectively. Economic analysis demonstrated that avermectin production cost generated from the fermentation process by SSF was 8.38 % lower than that by SmF. Moreover, avermectin SSF products could be directly used as microbial pesticides for biological control of underground pests and nematodes. This is the first report on avermectin production via SSF, demonstrating great potential in industrial and agricultural applications. Our work also provides guidance to produce other NPs through SSF in other Streptomyces species.

分类号：

  • 相关文献

[1]Avermectins及其抗性的研究进展. 吴青君,张文吉,张友军. 1998

[2]Influence of Cluster-Situated Regulator PteF in Filipin Biosynthetic Cluster on Avermectin Biosynthesis in Streptomyces avermitilis. Guozhong Du,Xue Yang,Zhengxiong Wu,Minghui Pan,Zhuoxu Dong,Yanyan Zhang,Wensheng Xiang,Shanshan Li. 2024

[3]Adsorption of avermectins on activated carbon: Equilibrium, kinetics, and UV-shielding. Gu Wei,Sun Chang-jian,Liu Qi,Cui Hai-xin. 2009

[4]Multifunctional ?-Cyclodextrin-Based Metal-Organic Frameworks as Avermectins Carriers for Controlled Release and Enhanced Acaricidal Activity. Chen, Huiping,Shan, Yongpan,Xu, Chunli,Bilal, Muhammad,Zhao, Pengyue,Cao, Chong,Zhang, Hongjun,Huang, Qiliang,Cao, Lidong. 2023

[5]Harsh Sensitivity and Mechanism Exploration of an Antibacterial Peptide Extracted from Walnut Oil Residue Derived from Agro-Industrial Waste. Dongwei Liu,Mei Liu,Dehao Meng,Yihan Mu,Tao Wang,Zhaolin Lv. 2022

[6]Efficient production of lactic acid from anaerobic co-fermentation of starch and nitrogen-rich agro-industrial waste using a batch system. Tianjing Lian,Wanqin Zhang,Qitao Cao,Shunli Wang,Fubin Yin,Tanlong Zhou,Fangyu Zhang,Hongmin Dong. 2023

[7]Amino Acids Hydrolyzed from Animal Carcasses Are a Good Additive for the Production of Bio-organic Fertilizer. Liu, Hongjun,Chen, Dandan,Hang, Xinnan,Li, Rong,Shen, Qirong,Liu, Hongjun,Chen, Dandan,Hang, Xinnan,Li, Rong,Shen, Qirong,Zhang, Ruifu. 2016

[8]Vinegar production residue as substrates for phytase production by Aspergillus ficuum. Wang, Zhihong,Dong, Xiaofang,Tong, Jianming,Wu, Yingying,Zhang, Qi.

[9]Structural Properties of a Heteropolysaccharide Released from Isaria cicadae Miq. Solid-State Fermented Wheat Bran. Rui Liu,Ruixin Liu,Xuebing Yan,Ningjie Li,Ming Li,Zijian Zhi,Boli Guo,Min Zhang. 2023

[10]Improving the Nutritional Value of Plant Protein Sources as Poultry Feed through Solid-State Fermentation with a Special Focus on Peanut Meal—Advances and Perspectives. Chong Li,Shuzhen Li,Yanbin Zhu,Si Chen,Xiaoying Wang,Xuejuan Deng,Guohua Liu,Yves Beckers,Huiyi Cai. 2023

[11]Spatial-temporal distribution of deoxynivalenol, aflatoxin B1, and zearalenone in the solid-state fermentation basin of traditional vinegar and their potential correlation with microorganisms. Shen, Lingqin,Wang, Yifan,Li, Xin,Hou, Ziqing,Mao, Jin,Shi, Jiyong,Battino, Maurizio,Routledge, Michael N.,Gong, Yunyun,Zou, Xiaobo,Zhang, Di. 2024

[12]Environmental microbiota and its influence on microbial succession and metabolic profiles in baijiu fermentation across three distinct-age workshops. Shanshan Xu,Hao Zhou,Boyang Xu,Wuyang Liu,Weiqi Hu,Qinxiang Xu,Jiong Hong,Yongxin Liu,Xingjiang Li. 2024

[13]Solid-State Fermentation of Acid-Resistant Aspergillus niger A515: An Approach to Degrade AFB1 and ZEN and Enhance Nutritional Components in Maize Products. Gao, Yuan,Sun, Lu,Tian, Xiaoyu,Yang, Shuo,Du, Haolan,Zhao, Haiyan,Yang, Bolei,Xing, Fuguo. 2025

[14]Dynamic changes in nutritions and antioxidant activities of germinated black bean based on solid-state fermentation of Ganoderma oregonense. Xiaoqin Ren,Qiongling Chen,Feng Wang,Helin Guo,Yu Wang,Fengying Gu. 2025

[15]Antioxidant capacities and non-volatile metabolites changes after solid-state fermentation of soybean using oyster mushroom (Pleurotus ostreatus) mycelium. Mengxin He,Qing Peng,Xiaoqing Xu,Bo Shi,Yu Qiao. 2024

[16]Solid-state fermentation with Ganoderma lucidum improves nutritional quality and processing characteristics of wheat (Triticum aestivum L.). Mengting Weng,Jinxiao Cheng,Tongtong Lei,Pufu Lai,Hongyu Wang,Xuanming Tang,Di Zhang,Yanfang Pan. 2025

[17]Dose-Dependent Responses of Weaned Piglets to Multi-Species Solid-State Fermented Apple Pomace: Enhanced Growth Performance, Intestinal Health, and Gut Microbiota Modulation. Jiongjie He,Shengyi Wang. 2026

[18]Optimizing Enzymatic Pretreatment of Wet-Grade Maize Distiller's Dried Grains with Solubles and Maize Germ Meal for Enhanced Metabolizable Energy Utilization in Broilers. Zheng, Mengli,Zhang, Huixin,An, Jing,Wei, Haoran,Zhang, Tieying,Chen, Qinghua. 2025

[19]An Autoregulated Fine-Tuning Strategy For T.iter Improvement Of Secondary M etabolites Using Native Promoters In Streptomyces. Yang, Keqian,Xiang, Wensheng,Li, Zilong,Wang, Junyang,Wang, Weishan,Wang, Junyang,Li, Shanshan,Li, Shanshan. 2018

[20]Biological control of Botrytis cinerea on tomato plants using Streptomyces ahygroscopicus strain CK-15. Cheng, Y.,Liu, Y.,Liu, B. H.,Zhang, K. C..

作者其他论文 更多>>