数字农科院2.0

A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator

文献类型： 外文期刊

作者： Hanhui Ye;1;2 Jinjin Yuan;1;2 Zhengwu Wang;1;2 Aiqiong Huang;1;2 Xiaolong Liu;1;2 韩霄;3 and Yahong Chen1;2

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期刊名称： Computational and Mathematical Methods in Medicine

ISSN： 1748-670X

年卷期： 2016 年

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收录情况： 不在遴选数据库范围

摘要： Human immunodeficiency virus causes a severe disease in humans, referred to as immune deficiency syndrome. Studies on the interaction between host genetic factors and the virus have revealed dozens of genes that impact diverse processes in the AIDS disease. To resolve more genetic factors related to AIDS, a canonical correlation analysis was used to determine the correlation between AIDS restriction and metabolic pathway gene expression. The results show that HIV-1 postentry cellular viral cofactors from AIDS restriction genes are coexpressed in human transcriptome microarray datasets. Further, the purine metabolism pathway comprises novel host factors that are coexpressed with AIDS restriction genes. Using a canonical correlation analysis for expression is a reliable approach to exploring the mechanism underlying AIDS.

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