数字农科院2.0

Effect of feeding transgenic cry1Ab/cry1Ac rice on indices of immune function in broilers

文献类型： 外文期刊

作者： Liu Ran-ran;Zhao Gui-ping;Zheng Mai-qing;Liu Jie;Zhang Jing-jing;Li Peng;Li Qing-he;Feng Jing-hai;Zhang Min-hong;Wen Jie;Liu Ran-ran;Zhao Gui-ping;Zheng Mai-qing;Feng Jing-hai;Zhang Min-hong;Wen Jie

作者机构：

关键词： transgenic;cry1Ab/cry1Ac gene;rice;broiler;immune trait;gene expression

期刊名称： JOURNAL OF INTEGRATIVE AGRICULTURE

ISSN： 2095-3119

年卷期： 2016 年 15 卷 6 期

页码：

收录情况： SCI

摘要： The safety of feeding transgenic cry1Ab/cry1Ac rice (a genetically modified (GM) rice variety) to broilers was examined from an immunological perspective. Hatchling ArborAcres chickens (240) were assigned to two dietary treatments (diets containing GM or non-GM rice) with 12 replicates per group and 10 birds per replicate. Traits were measured on one randomly selected bird from each replicate at d 21 and 42. The 42-d feeding trial revealed that cry1Ab/cry1Ac rice had no significant effect relative to non-GM rice on body weight and the immune organ indices. No significant pathological lesion in the spleen and bursa of Fabricius was found in the GM rice group. There were no significant differences in serum concentrations of innmunoglobulin Y (IgY), IgM, interleukin 4 (IL-4) and IL-6 between the two groups at d 21 or 42, except for IL-6 being higher (P<0.05) in the GM-fed chickens at d 42. There were no differences in the T and B lymphocyte transformation rate and CD4(+)/CD8(+) ratio between the two groups at d 42. Additionally, there was no significant difference between the two diets in expression of relevant genes viz. the major histocompatibility complex class II beta chain (BLB2), interferon beta 1 (IFN beta), tumour necrosis factor alpha-like (TNF alpha) and toll-like receptor 4 (TLR4) in the spleen and bursa of Fabricius. All the data demonstrated that transgenic cry1Ab/cry1Ac rice had no adverse effect on these aspects of immune function of broilers during 42-d feeding trial. Transgenic rice was therefore indistinguishable from non-GM rice in terms of short-term feeding in chickens.

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