数字农科院2.0

Comprehensive analysis of the circular RNA expression profile and circRNA–miRNA–mRNA network in the goat skin with divergent wool curvature

文献类型： 外文期刊

作者： Yingxiao Su;Zhanqiang Zhao;Zhanfa Liu;Xiaobo Li;Qian Chen;Yabin Pu;Lin Jiang;Xiaohong He;Yuehui Ma;Qianjun Zhao

作者机构：

关键词： circRNAs;goat;network;skin;wool curvature

期刊名称： Animal Research and One Health

ISSN： 2835-5075

年卷期： 2025 年 3 卷 3 期

页码：

收录情况： 无来源刊（2025版）

摘要： Wool curvature is one of the most valuable characteristics of Zhongwei goat fur. As the goats grow, the curvature progressively diminishes, which has a substantial impact on the quality and market value of wool. Circular RNAs (circRNAs) are a class of noncoding RNA and play vital roles in animal growth and development. However, the expression and function of circRNAs in the wool curvature of Zhongwei goats are unclear. In our study, we conducted circRNA expression profiling of Zhongwei goat skin exhibiting divergent curvature wool phenotypes at two developmental stages using the RNA-seq. In total, 12,682 circRNAs and 158 differentially expressed circRNAs (DE circRNAs) were identified. KEGG analysis illustrated that host genes of DE circRNAs were significantly enriched in the signaling pathways of Ras, JAK/STAT5, and cAMP, which might affect wool curvature. We further validated five circRNAs using qRT-PCR, which were consistent with the sequencing results. Functional verification assay demonstrated that circRNA8782 regulated fibroblast proliferation. In addition, we constructed a regulatory competing endogenous RNA (ceRNA) network and predicted circRNA3173-miR-16b-5p-IGF1 axes involved in the regulation of wool curvature. Our result will provide the foundation for uncovering the regulatory mechanisms of underlying wool curvature patterns in goats.

分类号：

  • 相关文献

[1]Identification of circRNAs Associated with Adipogenesis Based on RNA-seq Data in Pigs. Li Q.,Wang L.,Xing K.,Yang Y.,Abiola Adetula A.,Liu Y.,Yi G.,Zhang H.,Sweeney T.,Tang Z.. 2022

[2]环状RNA及其在生态毒理学研究中的应用进展. 王瑞,李亮. 2021

[3]De novo assembly and characterization of skin transcriptome using RNAseq in sheep (Ovis aries). Yue, Y. J.,Yang, B. H.,Yue, Y. J.,Liu, J. B.,Yang, M.,Han, J. L.,Guo, T. T.,Guo, J.,Feng, R. L.,Yang, B. H.. 2015

[4]Comparative Study Of Transcriptome Profiles O.f Mouse Livers And S kins Infected By Fork-Tailed Or Non-Fork-Tailed Schistosoma Japonicum. Yang, Y,He, JJ,Hu, S,Chang, H,Xiang, X,Yang, JF,Zou, FC. 2017

[5]Substances for regenerative wound healing during antler renewal stimulated scar-less restoration of rat cutaneous wounds. Qianqian Guo,Zhen Liu,Junjun Zheng,Haiping Zhao,Chunyi Li. 2021

[6]Integration Analysis of Transcriptome and Proteome Reveal the Mechanisms of Goat Wool Bending. Liu Y.,Ding Y.,Liu Z.,Chen Q.,Li X.,Xue X.,Pu Y.,Ma Y.,Zhao Q.. 2022

[7]Dwarf Interstocks Improve Aroma Quality of 'Huahong' Apple (Malus x domestica). Lu, Xiang,Gao, Yuan,Wang, Kun,Sun, Simiao,Liu, Zhao,Yan, Peng,Feng, Jianrong,Li, Qingshan,Li, Lianwen,Wang, Dajiang. 2022

[8]A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development. Chen, Qian,Liu, Yang,Maere, Steven,Van Isterdael, Gert,Xuan, Wei,Vassileva, Valya,Kitakura, Saeko,Wabnik, Krzysztof,Friml, Jiri,Beeckman, Tom,Vanneste, Steffen,Chen, Qian,Liu, Yang,Maere, Steven,Van Isterdael, Gert,Xuan, Wei,Vassileva, Valya,Kitakura, Saeko,Wabnik, Krzysztof,Friml, Jiri,Beeckman, Tom,Vanneste, Steffen,Chen, Qian,Li, Chuanyou,Liu, Yang,Lee, Eunkyoung,Lucas, Jessica,Sack, Fred,Xie, Zidian,Grotewold, Erich,Xie, Zidian,Grotewold, Erich,Vassileva, Valya,Kitakura, Saeko,Marhavy, Peter,Wabnik, Krzysztof,Benkova, Eva,Friml, Jiri,Marhavy, Peter,Geldner, Niko,Le, Jie,Fukaki, Hidehiro.

[9]Design and construction of the national agricultural information system. Guo, Xichuan. 2007

[10]geneHapR: an R package for gene haplotypic statistics and visualization. Renliang Zhang,Guanqing Jia,Xianmin Diao. 2023

[11]Different Gene Expression Patterns between Leaves and Flowers in Lonicera japonica Revealed by Transcriptome Analysis. Libin Zhang1, 2 †, Yan Long3 †, Chunhua Fu1 †, Jun Xiang2 , Jianping Gan2 , Gang Wu1 , Haibo Jia1 , Longjiang Yu1 and Maoteng Li 1, 2 *. 2016

[12]Soil sodicity affected the arbuscular mycorrhizal community and its interactions with bacteria in the Western Songnen Plain. Jiang, Nana,Guo, Quankuan,Yu, Yang,Guan, Yupeng,Yang, Wei. 2022

[13]Non-Volatile Metabolic Profiling and Regulatory Network Analysis in Fresh Shoots of Tea Plant and Its Wild Relatives. Chen Kai Jiang,Zhi Long Liu,Xuan Ye Li,Sezai Ercisli,Jian Qiang Ma,Liang Chen. 2021

[14]Application of thifluzamide alters microbial network structure and affects methane cycle genes in rice-paddy soil. Ying Zhang,Xiaohu Wu,Caijun Chen,Jun Xu,Fengshou Dong,Xingang Liu,Xiaogang Li,Yongquan Zheng. 2022

[15]Integrative Analysis of Expression Profiles of mRNA and MicroRNA Provides Insights of Cotton Response to Verticillium dahliae. Jun Mei,Yuqing Wu,Qingqing Niu,Meng Miao,Diandian Zhang,Yanyan Zhao,Fangfang Cai,Dongliang Yu,Liping Ke,Hongjie Feng,Yuqiang Sun. 2022

[16]Cell-Type Specific miRNA Regulatory Network Responses to ABA Stress Revealed by Time Series Transcriptional Atlases in Arabidopsis. Gao, Zhaoxu,Su, Yanning,Jiao, Guanzhong,Lou, Zhiying,Chang, Le,Yu, Renbo,Xu, Chao,Han, Xue,Wang, Zejia,Li, Jian,Deng, Xing Wang,He, Hang. 2025

[17]Nitrogen deposition reduces biodiversity but strengthens plant–microbe interactions. Zonghao Hu,Yi Fan,Junjie Yang,Shuang Pang,Rong Mao,Yang Zhang,Xingguo Han,Ximei Zhang. 2025

[18]Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages. Liang, Guoming,Yang, Yalan,Niu, Guanglin,Tang, Zhonglin,Li, Kui,Liang, Guoming,Yang, Yalan,Tang, Zhonglin,Li, Kui,Liang, Guoming,Yang, Yalan,Tang, Zhonglin.

[19]Genome-Wide Profiling Of Sus Scrofa C.ircular Rnas Across Nine O rgans And Three Developmental Stages. Liang, GM, Yang, YL, Niu, GL, Tang, ZL, Li, K. 2017

[20]Circular RNA transcriptome across multiple tissues reveal skeletal muscle-specific circPSME4 regulating myogenesis. Mu Zeng,Shanying Yan,Peng Yang,Qiaowei Li,Jiju Li,Xinhao Fan,Xiaoqin Liu,Yilong Yao,Wei Wang,Ruipu Chen,Guohao Han,Yalan Yang,Zhonglin Tang. 2023

作者其他论文 更多>>