Transcriptomic profiling of cardiac development in Bama Xiang pigs across key developmental stages
文献类型: 外文期刊
作者: Sheng Nan Wang;Wen Jie Tian;Deng Ke Pan;Tang Hai;Yue Hui Ma;Dan Dan Wang;Lin Jiang
作者机构:
关键词: Bama Xiang pig;Cardiac tissue;Heart development;Multiple stages;Transcriptomics
期刊名称: Zoological research
ISSN: 2095-8137
年卷期: 2025 年 46 卷 3 期
页码:
收录情况: SCIE(2025版) ; ; CSCD(2025-2026年度) ; ; 科技核心(2024版)
摘要: 近年来,越来越多的研究尝试将猪作为心脏异种移植的理想动物来源。然而,目前对猪心肌发育的研究大多集中在个别时间节点。为了系统地探究猪心肌组织在整个发育阶段的基因表达变化,我们对猪出生后的四个关键发育时期进行了详细的统计分析,涵盖了出生期、青春期、性成熟期和成年期。研究发现,随着发育过程的推进,心脏重量逐渐增加,心肌纤维面积和心腔尺寸也相应扩大。通过构建心肌组织的转录组图谱,并利用趋势聚类分析,将2 189个差异表达基因分为四个基因簇,这些基因显著与心肌发育、免疫、细胞增殖和代谢相关的通路相关。在四个时间点共有的359个差异表达基因中,我们共定位到6个与猪心肌发育密切相关的关键候选基因。利用RT-qPCR验证了这些候选基因的表达,结果显示这些候选基因与心肌发育显著相关。我们的研究为猪心肌生长发育提供了重要的数据支持,并为心脏异种移植提供了潜在的理论依据。.
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