数字农科院2.0

Identification of Major Metabolites of Salbutamol in Swine Urine and Plasma Using Ultra-High Performance Liquid Chromatography-Electrospray Time of Flight Mass Spectrometry

文献类型: 外文期刊

作者: Gu Xu;Liu Yi-Ming;Yao Ting;Shi Hua-Le;Li Jun;Zhao Zhen;Qin Yu-Chang

作者机构:

关键词: Salbutamol;Ultra-high performance liquid chromatography-electrospray time of flight mass spectrometry;Metabolites

期刊名称: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY

ISSN: 0253-3820

年卷期: 2014 年 42 卷 11 期

页码:

收录情况: SCI

摘要: The excretion of urinary and plasmic metabolites of salbutamol was studied using ultra performance liquid chromatography electrospray ionization quadrupole time-of-flight tandem mass spectrometry, after a single intragastric gavaged dose administration with salbutamol. The software of Agilent Mass Hunter Metabolite ID was employed to find and identify the chemical structure of metabolites of salbutamol. Five metabolites from salbutamol were identified. The metabolites identified in swine urine included glucuronide conjugate salbutamol, N-oxide-salbutamol, hydroxyl-salbutamol, methoxyl-salbutamol and dehydrated hydroxyl-salbutamol. Whereas, only the parent drugs, glucuronide conjugate salbutamol and N-oxide salbutamol were observed in plasma.

分类号:

  • 相关文献

[1]Residues of Salbutamol and Identification of Its Metabolites in Beef Cattle. Zhang, Kai,Tang, Chaohua,Meng, Qingshi,Zhao, Qingyu,Liang, Xiaowei,Liu, Shengsheng,Zhang, Junmin,Du, Wei,Bo, Tao,Zhang, Zhixu.

[2]Application of a NMR-based untargeted quantitative metabonomic approach to screen for illicit salbutamol administration in cattle. Tang, Chaohua,Zhang, Kai,Liang, Xiaowei,Zhao, Qingyu,Zhang, Junmin.

[3]Validation of a confirmatory method of salbutamol in sheep hair by UPLC-MS/MS and its application to pharmacokinetic study. Suo Decheng,Zhang Wei,Zhang Yu,Zhao Genlong,Wang Ruigou,Wang PeiLong,Su Xiaoou.

[4]Colorimetric detection of ractopamine and salbutamol using gold nanoparticles functionalized with melamine as a probe. Wang, Peilong,Su, Xiaoou,Zhou, Ying,Zhao, Hong,He, Yujian,He, Yujian.

[5]Ultrasensitive Detection Of Salbutamol In A.nimal Urine By Immunomagnetic B ead Treatment Coupling With Surface-Enhanced Raman Spectroscopy. Cheng, J, Su, XO, Han, CQ, Wang, S, Wang, PL, Zhang, S, Xie, JC. 2018

[6]Isobaric Tags For Relative And A.bsolute Quantification (Itraq)-Based Untargeted Q uantitative Proteomic Approach To Identify Change Of The Plasma Proteins By Salbutamol Abuse In Beef Cattle. Zhang, K, Tang, CH, Liang, XW, Zhao, QY, Zhang, JM. 2018

[7]Residues Of Salbutamol And Identification O.f Its Metabolites In B eef Cattle. Zhang, K, Tang, CH, Meng, QS, Du, W, Bo, T, Zhao, QY, Liang, XW, Liu, SS, Zhang, ZX, Zhang, JM. 2017

[8]Development Of A Highly Sensitive T.ime-Resolved Fluoroimmunoassay For The D etermination Of Trace Salbutamol In Environmental Samples. Fang, S, Zhang, YZ, Liu, X, Qiu, J, Liu, ZJ, Kong, FY. 2019

[9]Influence of different dietary levels of zinc on performance, vitamin B-12, and blood parameters in lambs. Wang, Runlian,Zhu, Xiaoping,Guo, Fucun,Zhang, Wei,Jia, Zhihai. 2006

[10]Pharmacokinetics of Mequindox and Its Metabolites in Swine. Liu Yi-ming,Liu Ying-chun,Ding Huan-zhong,Fang Bing-hu,Yang Fan,Shan Qi,Zeng Zhen-ling,Liu Ying-chun. 2011

[11]Determination of Trace Atrazine and Two Kinds of Its Metabolites in Milk by Solid Phase Extraction and Liquid Chromatography/Mass Spectrometry. Shi Dong-Dong,Liu Qing-Sheng,Shi Bo,Chang Bi-Ying. 2013

[12]Simultaneous Determination of Triclabendazole and its Metabolites in Bovine and Goat Fat Tissues by Liquid Chromatography-Tandem Mass Spectrometry. Cai, Chengyuan,Xue, Feiqun,Wang, Zhongyan,Xiao, Sui,Zhang, Lifang,Wang, Zhongyan. 2012

[13]Comparative metabolic responses and adaptive strategies of wheat (Triticum aestivum) to salt and alkali stress. Guo, Rui,Li, Feng,Yan, Changrong,Zhong, Xiuli,Liu, Qi,Xia, Xu,Li, Haoru,Yang, Zongze,Zhao, Long. 2015

[14]Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration. Li, Guanghui,Yang, Fan,He, Limin,Ding, Huanzhong,Sun, Na,Liu, Yingchun,Liu, Yiming,Shan, Qi,Li, Yafei,Zeng, Zhenling,Li, Guanghui,Yang, Fan,Liu, Yingchun,Liu, Yiming. 2012

[15]Imazamox microbial degradation by common clinical bacteria: Acinetobacter baumannii IB5 isolated from black soil in China shows high potency. Liu Chun-guang,Yang Xin,Lai Yang,Lu Hong-gang,Zeng Wei-min,Yang Feng-shan,Liu Chun-guang,Zeng Wei-min,Yang Feng-shan,Liu Chun-guang,Geng Gui,Geng Gui. 2016

[16]Simultaneous determination of 14 antiviral drugs and relevant metabolites in chicken muscle by UPLC-MS/MS after QuEChERS preparation. Qian, Yongzhong,Qiu, Jing.

[17]Behaviour of spirotetramat residues and its four metabolites in citrus marmalade during home processing. Liu, Yanyu,Chen, Weijun,Sun, Dali,Gong, Lei,Jiang, Liyan,Jiao, Bining,Liu, Yanyu,Chen, Weijun,Sun, Dali,Gong, Lei,Jiang, Liyan,Jiao, Bining,Su, Xuesu,Jian, Qiu,Chen, Weijun,Jiao, Bining,Jiao, Bining.

[18]Anti-inflammatory effects of 4 '-demethylnobiletin, a major metabolite of nobiletin. Wu, Xian,Song, Mingyue,Rakariyatham, Kanyasiri,Zheng, Jinkai,Guo, Shanshan,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan,Tang, Zhonghai,Zhou, Shuangde,Xiao, Hang.

[19]Liquid chromatography-tandem mass spectrometry analysis of nitazoxanide and its major metabolites in goat. Zhao, Zhanzhong,Zhang, Lifang,Xue, Feiqun,Wang, Xiaoyang,Zheng, Wenli,Zhang, Tao,Fei, Chenzhong,Zhang, Keyu,Qiu, Minqi,Xin, Ruixiang,Yang, Fengkun. 2008

[20]Metabolism of mequindox and its metabolites identification in chickens using LC-LTQ-Orbitrap mass spectrometry. Shan, Qi,Liu, Yiming,He, Limin,Ding, Huanzhong,Huang, Xianhui,Yang, Fan,Li, Yafei,Zeng, Zhenling,Liu, Yiming.

作者其他论文 更多>>