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Assessment of genotoxic effects of flumorph by the comet assay in mice organs

文献类型： 外文期刊

作者： Zhao, Q.;Ning, J.;Zhang, Y.

作者机构：

关键词： flumorph;alkaline comet assay;genotoxicity;DNA damage

期刊名称： HUMAN & EXPERIMENTAL TOXICOLOGY

ISSN： 0960-3271

年卷期： 2014 年 33 卷 3 期

页码：

收录情况： SCI

摘要： The present study investigated the genotoxic effects of flumorph in various organs (brain, liver, spleen, kidney and sperm) of mice. The DNA damage, measured as comet tail length (mu m), was determined using the alkaline comet assay. The comet assay is a sensitive assay for the detection of genotoxicity caused by flumorph using mice as a model. Statistically significant increases in comet assay for both dose-dependent and duration-dependent DNA damage were observed in all the organs assessed. The organs exhibited the maximum DNA damage in 96 h at 54 mg/kg body weight. Brain showed maximum DNA damage followed by spleen > kidney > liver > sperm. Our data demonstrated that flumorph had induced systemic genotoxicity in mammals as it caused DNA damage in all tested vital organs, especially in brain and spleen.

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