数字农科院2.0

Genome-Wide Association Study for Certain Carcass Traits and Organ Weights in a Large WhitexMinzhu Intercross Porcine Population

文献类型： 外文期刊

作者： Liu Xin;Wang Li-gang;Liang Jing;Yan Hua;Zhao Ke-bin;Li Na;Zhang Long-chao;Wang Li-xian;Li Na

作者机构：

关键词： genome-wide association study (GWAS);carcass trait;HMGA1 gene;organ weight;pig

期刊名称： JOURNAL OF INTEGRATIVE AGRICULTURE

ISSN： 2095-3119

年卷期： 2014 年 13 卷 12 期

页码：

收录情况： SCI

摘要： Porcine carcass traits and organ weights have important economic roles in the swine industry. A total of 576 animals from a Large WhitexMinzhu intercross population were genotyped using the Illumina PorcineSNP60K Beadchip and were phenotyped for 10 traits, specifically, backfat thickness (6-7 libs), carcass length, carcass weight, foot weight, head weight, heart weight, leaf fat weight, liver weight, lung weight and slaughter body weight. The genome-wide association study (GWAS) was assessed by Genome Wide Rapid Association using the mixed model and regression-genomic control approach. A total of 31 single nucleotide polymorphisms (SNPs) (with the most significant SNP being MARC0033464, P value=6.80x10(-13)) were located in a 9.76-Mb (31.24-41.00 Mb) region on SSC7 and were found to be significantly associated with one or more carcass traits and organ weights. High percentage of phenotypic variance explanation was observed for each trait ranging from 31.21 to 67.42%. Linkage analysis revealed one haplotype block of 495 kb, in which the most significant SNP being MARC0033464 was contained, on SSC7 at complete linkage disequilibrium. Annotation of the pig reference genome suggested 6 genes (GRM4, HMGA1, NUDT3, RPS10, SPDEF and PACSIN1) in this candidate linkage disequilibrium (LD) interval. Functional analysis indicated that the HMGA1 gene presents the prime biological candidate for carcass traits and organ weights in pig, with potential application in breeding programs.

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