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N-glycome and N-glycoproteome of a hematophagous parasitic nematode Haemonchus

文献类型： 外文期刊

作者： Wang Chunqun;Gao Wenjie;Yan Shi;Zhu Xing-Quan;Suo Xun;Liu Xin;Gupta Nishith;Hu Min

作者机构：

关键词： Glycopeptide; Haemonchus contortus; Mass spectrometry; N-glycan; N-glycosylation

期刊名称： Computational and Structural Biotechnology Journal

ISSN： 2001-0370

年卷期： 2021 年 19 卷

页码：

收录情况： JCR（2021版） ; EI（2021版）

摘要： N-glycosylation is a physiologically vital post-translational modification of proteins in eukaryotic organisms. Initial work on Haemonchus contortus – a blood-sucking nematode of ruminants with a broad geographical distribution – has shown that this parasite harbors N-glycans with exclusive chitobiose modifications. Besides, several immunogenic proteins (e.g., amino- and metallo-peptidases) are known to be N-glycosylated in adult worms. However, an informative atlas of N-glycosylation in H. contortus is not yet available. Herein, we report 291 N-glycosylated proteins with a total of 425 modification sites in the parasite. Among them, many peptidase families (e.g., peptidase C1 and M1) including potential vaccine targets were enriched. Notably, the glycan-rich conjugates are distributed primarily in the intestine and gonads of adult worms, and consequently hidden from the host's immune system. Collectively, these data provide a comprehensive atlas of N-glycosylation in a prevalent parasitic nematode while underlining its significance for infection, immunity and prevention. © 2021 The Author(s)

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