数字农科院2.0

Effects of Al on the splenic immune function and NE in rats

文献类型： 外文期刊

作者： Hu, Chongwei;Li, Jing;Hu, Chongwei;Zhu, Yanzhu;Bai, Chongsheng;Zhang, Jihong;Xia, Shiliang;Li, Yanfei;Zhu, Yanzhu

作者机构：

关键词： Al;Spleen;Immune function;NE

期刊名称： FOOD AND CHEMICAL TOXICOLOGY

ISSN： 0278-6915

年卷期： 2013 年 62 卷

页码：

收录情况： SCI

摘要： Norepinephrine (NE) regulates the splenic immune function and it may be related to the effects of Aluminum (Al) on the splenic immune function. Here, the aim of this study was to further explore the effects of aluminum trichloride (AlCI3) on the splenic immune function and its relationship with NE. Forty male Wistar rats were orally exposed to AlCl3 (0, 64.18, 128.36 and 256.72 mg/kg BW) through drinking water for 120 days. The CD3(+), CD4(+), CD8(+) T lymphocytes, the T and B lymphocytes proliferation rates and serum NE concentration were examined. The correlation analysis between splenic immune function and NE were done. The results showed that the CD3(+), CD4(+), CD8(+) T lymphocytes and the T and B lymphocytes proliferation rates decreased and NE concentration increased in AlCl3-treated rats. NE was negatively correlated with proportions of CD3(+), CD4(+) T lymphocytes and T and B lymphocytes proliferation rates, but not correlated with CD8(+) T lymphocytes. The results suggest that AlCl3 suppresses the splenic immune function and NE plays important role in this process. (C) 2013 Elsevier Ltd. All rights reserved.

分类号：

  • 相关文献

[1]Immunotoxicity of aluminum. Zhu, Yanzhu,Miao, Liguang,Wang, Yingping,Liu, Yanhuan,Yan, Xijun,Cui, Xuezhe,Li, Haitao,Zhu, Yanzhu,Li, Yanfei.

[2]Boron Affects Immune Function Through Modulation of Splenic T Lymphocyte Subsets, Cytokine Secretion, and Lymphocyte Proliferation and Apoptosis in Rats. Jin, Erhui,Li, Shenghe,Ren, Man,Hu, Qianqian,Gu, Youfang,Li, Shenghe,Li, Kui.

[3]GlobalgeneexpressionprofileofchickenspleentissueatalaterstageofIBVinfectionrevealspathogenesisandimmunemechanisms. FengCong,ZongxiHan,FengjieWang,YuhaoShao,XiangangKong,ShengwangLiu. 2014

[4]NE Strengthens the Immunosuppression Induced by AlCl3 Through beta(2)-AR/cAMP Pathway in Cultured Rat Peritoneal Macrophages. Li, Miao,Yang, Xu,Zhuang, Cuicui,Cao, Zheng,Ren, Limin,Xiu, Chunyu,Li, Yanfei,Zhu, Yanzhu.

[5]Aluminum Chloride- and Norepinephrine-Induced Immunotoxicity on Splenic Lymphocytes by Activating beta(2)-AR/cAMP/PKA/NF-kappa B Signal Pathway in Rats. Xiu, Chunyu,Ren, Limin,Li, Miao,Liu, Jianyu,Li, Yanfei,Liu, Shiming,Zhu, Yanzhu,Liu, Jianyu.

[6]The genetic basic and fine-mapping of a stable quantitative-trait loci for aluminium tolerance in rice. Xue, Y.,Jiang, L.,Su, N.,Wang, J. K.,Deng, P.,Ma, J. F.,Zhai, H. Q.,Wan, J. M..

[7]CLONCASE: Estimation of sex frequency and effective population size by clonemate resampling in partially clonal organisms. Leconte, Marc,Gautier, Angelique,De Vallavieille-Pope, Claude,Ali, Sajid,Soubeyrand, Samuel,Gladieux, Pierre,Giraud, Tatiana,Enjalbert, Jerome,Gladieux, Pierre,Mboup, Mamadou,Chen, Wanquan,Enjalbert, Jerome.

[8]IAA Accumulation Promotes the Root Growth of Tea Plants under Aluminum. Yaoyao Gao,Min Wang,Yifan Shi,Liu Yang,Jianhui Hu,Kai Fan,Yuanzhi Shi. 2022

[9]Analysis of miRNA expression profiling in mouse spleen affected by acute Toxoplasma gondii infection. He, Jun-Jun,Ma, Jun,Wang, Jin-Lei,Xu, Min-Jun,Zhu, Xing-Quan,Ma, Jun,Xu, Min-Jun,Zhu, Xing-Quan.

[10]Transcriptomic analysis of global changes in cytokine expression in mouse spleens following acute Toxoplasma gondii infection. He, Jun-Jun,Ma, Jun,Song, Hui-Qun,Zhou, Dong-Hui,Wang, Jin-Lei,Huang, Si-Yang,Zhu, Xing-Quan,Ma, Jun,Zhu, Xing-Quan.

[11]Expression analyses and antiviral properties of the Beijing-You and White Leghorn myxovirus resistance gene with different amino acids at position 631. Du, L. X.,Zhao, G. P.,Zhang, C. S..

[12]Transcriptional changes of mouse splenocyte organelle components following acute infection with Toxoplasma gondii. He, Jun-Jun,Ma, Jun,Li, Fa-Cai,Song, Hui-Qun,Xu, Min-Jun,Zhu, Xing-Quan,Ma, Jun,Xu, Min-Jun.

[13]Physiological interactions between the hypothalamic-pituitary-gonadal axis and spleen in rams actively immunized against GnRH. Ren, Xiaohua,Zhou, Yuqin,Cao, Xiaohan,Du, Xiaogang,Meng, Fengyan,Tan, Yao,Liu, Yacheng,Zeng, Xianyin,Zeng, Yu,Song, TianZeng,Feng, Jing,Chu, Mingxing.

[14]Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats. Zhu, Yanzhu,Li, Yanfei,Zhu, Yanzhu,Miao, Liguang,Li, Xinwei,Chen, Chongxiao,Wang, Fan,Li, Jing,Hu, Chongwei. 2012

[15]RNA sequencing reveals dynamic expression of spleen lncRNAs and mRNAs in Beagle dogs infected by Toxocara canis. Yue Xu,Wen Bin Zheng,Hao Yu Li,Lang Cai,Yang Zou,Shi Chen Xie,Xing Quan Zhu,Hany M. Elsheikha. 2022

[16]Metabolomic analysis of pig spleen reveals African swine fever virus infection increased acylcarnitine levels to facilitate viral replication. Xing Yang,Xintian Bie,Huanan Liu,Xijuan Shi,Dajun Zhang,Deng Shuai Zhao,Yu Hao,Jinke Yang,Wenqian Yan,Guohui Chen,Lingling Chen,Zixiang Zhu,Fan Yang,Xusheng Ma,Xiangtao Liu,Haixue Zheng,Keshan Zhang. 2023

[17]Transcriptomic Analysis of the Spleen of Different Chicken Breeds Revealed the Differential Resistance of Salmonella Typhimurium. Elsharkawy, Mohamed Shafey,Wang, Hailong,Ding, Jiqiang,Madkour, Mahmoud,Wang, Qiao,Zhang, Qi,Zhang, Na,Li, Qinghe,Zhao, Guiping,Wen, Jie. 2022

[18]Gut-Spleen Axis: Microbiota via Vascular and Immune Pathways Improve Busulfan-Induced Spleen Disruption. Fang, Hanhan,Feng, Xiaohui,Xu, Tao,Zhong, Ruqing,Lu, Dongxin,Zhang, Hongfu,Shen, Wei,Zhao, Yong,Chen, Liang,Wang, Junjie. 2023

[19]Streptococcus suis: A Review of Its Effects on Immune Organs. Siyu Pan,Haijuan He,Tong Qing An,Shujie Wang. 2025

[20]Transcriptome analysis reveals no obvious unintended effects in the spleen of CRISPR/Cas9-mediated CD163 and pAPN double-knockout pigs. Zhi Guo Liu,Nan Wang,Wan Jie Wang,Lei Huang,Shun Shun Chi,Yu Xin Nie,Mao Sha Yuan,Ya Ru Sun,Yu Lian Mu,Kui Li. 2025

作者其他论文 更多>>