数字农科院2.0

Determination of Trace Atrazine and Two Kinds of Its Metabolites in Milk by Solid Phase Extraction and Liquid Chromatography/Mass Spectrometry

文献类型： 外文期刊

作者： Shi Dong-Dong;Liu Qing-Sheng;Shi Bo;Chang Bi-Ying

作者机构：

关键词： Liquid chromatography-tandem mass spectrometry;Milk;Atrazine;Metabolites

期刊名称： CHINESE JOURNAL OF ANALYTICAL CHEMISTRY

ISSN： 0253-3820

年卷期： 2013 年 41 卷 1 期

页码：

收录情况： SCI

摘要： A sensitive LC-MS method was developed for the determination of atrazine and its metabolites in cattle milk. The method can be applied to the simultaneous determination of atrazine and its major dealkylation and hydroxylation metabolites which include atrazine, hydroxyatrazine, diaminochloroatrazine, desisopropylatrazine, desethylatrazine, deethylhydroxyatrazine, deisopropylhydroxyatrazine. The analytical scheme including sample preparation, chromatographic and mass spectrometric conditions was developed and optimized. Hydrochloric acid and sodium thiosulphate were added to the sample before extracted by ice acetonitrile. The mixed cation-exchange column was found to be satisfactory for the purification of sample. High-performance liquid chromatography/mass spectrometric methods were used for the quantitative analysis of samples. The relative standard deviations for the analytes were from 1.53% to 9.04% at 1, 5, 10 and 25 mu g/L level, the recoveries range was from 62.0% to 119.0% at 1, 5, 10 and 25 mu g/L level, and the limits of detection (LOD) were from 0.1 to 0.5 mu g/L. The linear ranges of the method were from 0.4 to 100 mu g/L with R-2 values of greater than 0.99. The method is rapid, cost-effective and could be applied to assess the safety of milk exposure to atrazine related chemicals.

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