数字农科院2.0

Prevention of Schistosoma japonicum infection in mice with long-acting praziquantel implants

文献类型： 外文期刊

作者： Lei, Lei;Guo, Shengrong;Cheng, Liang;Hou, Jingwen;Zhu, Chuangang;Shi, Yaojun;Jiang, Yan;Lin, Jiaojiao

作者机构：

关键词： Schistosomiasis;Schistosoma japonicum;Infection prevention;Praziquantel;Implant

期刊名称： EXPERIMENTAL PARASITOLOGY

ISSN： 0014-4894

年卷期： 2012 年 131 卷 4 期

页码：

收录情况： SCI

摘要： This work reports the prevention outcomes of a praziquantel (PZQ) implant against the infection of Schistosoma japonicum in mice. The PZQ implant produced stable plasma PZQ concentrations in a range of 100-1300 ng/mL for a period of 70 days, by releasing PZQ in subcutaneous tissues in a sustained manner. To assess the prevention effects, the mice were infected at varying times after implantation. All the mice were sacrificed at 6 weeks after infection for worm and egg recovery and counting, worm morphological examination, determination of egg-hatching rates, and analysis of hepatic histology. The infection was successfully prevented for mice with early infection times (within 2-3 weeks), as nearly no worms, paired worms, eggs, or miracidia were recovered. However, in mice with late infection times (after 3 weeks), the prevention effects were diminished due to the decreased plasma PZQ concentrations at late times. Interestingly, the implants showed robust prevention effects on repeated infection at 1 and 3 weeks. In the infection-prevented mouse livers, no granuloma formation or granulomatous inflammation was observed. The results demonstrated that by blocking the development of infecting miracidia and by deactivating the eggs, the PZQ implants encouragingly prevented the S. japonicum infection and avoided liver damage. (C) 2012 Elsevier Inc. All rights reserved.

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