数字农科院2.0

The First High-quality Reference Genome of Sika Deer Provides Insights into High-tannin Adaptation

文献类型： 外文期刊

作者： Xing, Xiumei;Ai, Cheng;Wang, Tianjiao;Li, Yang;Liu, Huitao;Hu, Pengfei;Wang, Guiwu;Liu, Huamiao;Wang, Hongliang;Zhang, Ranran;Zheng, Junjun;Wang, Xiaobo;Wang, Lei;Chang, Yuxiao;Qian, Qian;Yu, Jinghua;Tang, Lixin;Wu, Shigang;Shao, Xiujuan;Li, Alun;Cui, Peng;Zhan, Wei;Zhao, Sheng;Wu, Zhichao;Shao, Xiqun;Dong, Yimeng;Rong, Min;Tan, Yihong;Cui, Xuezhe;Chang, Shuzhuo;Song, Xingchao;Yang, Tongao;Sun, Limin;Ju, Yan;Zhao, Pei;Fan, Huanhuan;Liu, Ying;Wang, Xinhui;Yang, Wanyun;Yang, Min;Wei, Tao;Song, Shanshan;Xu, Jiaping;Yue, Zhigang;Liang, Qiqi;Li, Chunyi;Ruan, Jue;Yang, Fuhe

作者机构：

关键词： Sika deer;Whole-genome sequencing;Chromosome-scale assembly;Oak leaf;Tannin tolerance

期刊名称： GENOMICS PROTEOMICS & BIOINFORMATICS

ISSN： 1672-0229

年卷期： 2023 年 21 卷 1 期

页码：

收录情况： SCIE（2023版） ; ; CSCD（2023-2024年度） ; ; 科技核心（2023版）

摘要： Sika deer are known to prefer oak leaves, which are rich in tannins and toxic to most mammals; however, the genetic mechanisms underlying their unique ability to adapt to living in the jungle are still unclear. In identifying the mechanism responsible for the tolerance of a highly toxic diet, we have made a major advancement by explaining the genome of sika deer. We generated the first high-quality, chromosome-level genome assembly of sika deer and measured the correlation between tannin intake and RNA expression in 15 tissues through 180 experiments. Comparative genome analyses showed that the UGT and CYP gene families are functionally involved in the adaptation of sika deer to high-tannin food, especially the expansion of the UGT family 2 subfamily B of UGT genes. The first chromosome-level assembly and genetic characterization of the tolerance to a highly toxic diet suggest that the sika deer genome may serve as an essential resource for understanding evolutionary events and tannin adaptation. Our study provides a paradigm of comparative expressive genomics that can be applied to the study of unique biological features in non-model animals.

分类号：

  • 相关文献

[1]Phenotype of White Sika Deer Due to SCF Gene Structural Variation. Xu Chen,Shiwu Dong,Xin Liu,Ning Ding,Xiumei Xing. 2023

[2]Metagenomic Investigation of Pathogenic RNA Viruses Causing Diarrhea in Sika Deer Fawns. Weiyang Wang,Qilin Wang,Runlai Cao,Yacong Li,Ziyu Liu,Zhuqing Xue,Xiaoxu Wang,Zhijie Liu. 2025

[3]Membrane Fluidity Of Saccharomyces Cerevisiae From Huangjiu (Chinese Rice Wine) Is Variably Regulated By Ole1 To Offset The Disruptive Effect Of Ethanol. Yang, Yijin,Tao, Leren,Yu, Jianshen,Xia, Yongjun,Yang, Yijin,Ai, Lianzhong,Hu, Wuyao,Ni, Li. 2019

[4]Whole-Genome Sequencing of Native Sheep Provides Insights into Rapid Adaptations to Extreme Environments. Yang, Ji,Lv, Feng-Hua,Peng, Wei-Feng,Zhao, Yong-Xin,Zhang, Min,Xie, Xing-Long,Li, Meng-Hua,Li, Wen-Rong,He, San-Gang,Sun, Ya-Wei,Liu, Ming-Jun,Tian, Shi-Lin,Tu, Xiao-Long,Liu, Guang-Jian,Lu, Hong-Feng,Peng, Wei-Feng,Zhao, Yong-Xin,Xie, Xing-Long,Sun, Ya-Wei,Zhang, Min,Wang, Yu-Tao,Li, Jin-Quan,Liu, Yong-Gang,Shen, Zhi-Qiang,Wang, Feng,Kantanen, Juha,Kantanen, Juha,Han, Jian-Lin,Han, Jian-Lin.

[5]Comprehensive analysis of structural variants in chickens using PacBio sequencing. Zhang J.,Nie C.,Li X.,Zhao X.,Jia Y.,Han J.,Chen Y.,Wang L.,Lv X.,Yang W.,Li K.,Zhang J.,Ning Z.,Bao H.,Zhao C.,Li J.,Qu L.. 2022

[6]Population Structure and Diversity in European Honey Bees (Apis mellifera L.)—An Empirical Comparison of Pool and Individual Whole-Genome Sequencing. Chao Chen,Melanie Parejo,Jamal Momeni,Jorge Langa,Rasmus O. Nielsen,Wei Shi,Rikke Vingborg,Per Kryger,Maria Bouga,Andone Estonba,Marina Meixner. 2022

[7]Current Status and Future Perspectives of Genomics Research in the Rust Fungi. Xia, Chongjing,Qiu, Age,Wang, Meinan,Liu, Taiguo,Chen, Wanquan,Chen, Xianming. 2022

[8]Genomic Architecture of Yield Performance of an Elite Rice Hybrid Revealed by its Derived Recombinant Inbred Line and Their Backcross Hybrid Populations. Fan Zhang,Conghe Zhang,Xiuqin Zhao,Shuangbing Zhu,Kai Chen,Guixiang Zhou,Zhichao Wu,Min Li,Tianqing Zheng,Wensheng Wang,Zhi Yan,Qinyong Fei,Zhikang Li,Jinjie Chen,Jianlong Xu. 2022

[9]Multi-generation study of heavy ion beam-induced mutations and agronomic trait variations to accelerate rice breeding. Ren, Weibin,Wang, He,Du, Yan,Li, Yan,Feng, Zhuo,Zhou, Xinhui,Kang, Guisen,Shu, Qingyao,Guo, Tao,Guo, Huijun,Yu, Lixia,Jin, Wenjie,Yang, Fu,Li, Jingpeng,Ma, Jianzhong,Li, Wenjian,Xu, Chaoli,Chen, Xia,Liu, Xiao,Yang, Chenan,Liu, Luxiang,Zhou, Libin. 2023

[10]Genomic Analysis of Escherichia coli Longitudinally Isolated from Broiler Breeder Flocks after the Application of an Autogenous Vaccine. Liča Lozica,Kasper Rømer Villumsen,Ganwu Li,Xiao Hu,Maja Maurić Maljković,Željko Gottstein. 2022

[11]Draft Genome and Biological Characteristics of Fusarium solani and Fusarium oxysporum Causing Black Rot in Gastrodia elata. Jinshao Li,Ke He,Qian Zhang,Xiaoyi Wu,Zhong Li,Xuejun Pan,Yong Wang,Cheng Li,Manman Zhang. 2023

[12]Pseudomonas isolates from raw milk with high level proteolytic activity display reduced carbon substrate utilization and higher levels of antibiotic resistance. Bingyao Du,Meng Lu,Huimin Liu,Haoming Wu,Nan Zheng,Yangdong Zhang,Shengguo Zhao,Yankun Zhao,Tengyun Gao,Jiaqi Wang. 2023

[13]Distinct non-synonymous mutations in cytochrome b highly correlate with decoquinate resistance in apicomplexan parasite Eimeria tenella. Zhenkai Hao,Junmin Chen,Pei Sun,Linlin Chen,Yuanyuan Zhang,Wenxuan Chen,Dandan Hu,Feifei Bi,Zhenyan Han,Xinming Tang,Jingxia Suo,Xun Suo,Xianyong Liu. 2023

[14]Genetic Diversity Estimation and Genome-Wide Selective Sweep Analysis of the Bazhou Yak. Baigao Yang,Hang Zhang,Xiaoyi Feng,Zhou Yu,Jianhua Cao,Yifan Niu,Pengcheng Wan,Gang Liu,Xueming Zhao. 2025

[15]Whole-genome sequencing of copy number variation analysis in Ethiopian cattle reveals adaptations to diverse environments. Wondossen Ayalew,Wu Xiaoyun,Getinet Mekuriaw Tarekegn,Tesfaye Sisay Tessema,Min Chu,Chunnian Liang,Rakan Naboulsi,Renaud Van Damme,Erik Bongcam-Rudloff,Yan Ping. 2024

[16]Comparative Analysis of Genomic Prediction for Production Traits Using Genomic Annotation and a Genome-Wide Association Study at Sequencing Levels in Beef Cattle. Zhida Zhao,Qunhao Niu,Tianyi Wu,Feng Liu,Zezhao Wang,Huijiang Gao,Junya Li,Bo Zhu,Lingyang Xu. 2024

[17]Genomic functional analysis of the first highly effective Bacillus thuringiensis strain targeting hemipteran pests reveals its plant growth-promoting potential. Cao, Beibei,Wang, Kui,Sun, Xiaoni,Shu, Changlong,Zhang, Jie. 2025

[18]Genome-wide association analysis identifies genetic variants associated with muscle fatty acids and amino acids in grass carp (Ctenopharyngodon idella). Jin Zhang,Qi Wang,Yi Ming Cao,Ming Xi Hou,Ran Zhao,Ying Jie Chen,Shuang Ting Yu,Kai Kuo Wang,Qin Zhang,Sheng Jie Li,Xiao Qing Sun,Yan Zhang,Jiong Tang Li. 2024

[19]Screening and Whole-Genome Analysis of Probiotic Lactic Acid Bacteria with Potential Antioxidants from Yak Milk and Dairy Products in the Qinghai–Tibet Plateau. Diyan Wu,Haichuan Li,Xuan Wang,Runtong Chen,Di Gong,Danfeng Long,Xiaodan Huang,Zhenchuang Tang,Ying Zhang. 2025

[20]Chromosome-level genome assembly of the glass catfish ( Kryptopterus vitreolus) reveals molecular clues to its transparent phenotype. Chao Bian,Rui Han Li,Zhi Qiang Ruan,Wei Ting Chen,Yu Huang,Li Yue Liu,Hong Ling Zhou,Cheong Meng Chong,Xi Dong Mu,Qiong Shi. 2024

作者其他论文 更多>>