数字农科院2.0

Characterization of a new dog isolate of canine distemper virus from China

文献类型： 外文期刊

作者： Qiao, J.;Meng, Q.;Chen, C.;Xia, X.;Ren, Y.;Zhang, H.;Qiao, J.;Cai, X.

作者机构：

关键词： canine distemper virus;hemagglutinin gene;virulence;Chinese isolate;dogs

期刊名称： ACTA VIROLOGICA

ISSN： 0001-723X

年卷期： 2011 年 55 卷 4 期

页码：

收录情况： SCI

摘要： Canine distemper virus (CDV) is a highly contagious pathogen of dogs. Vaccination is an effective way to protect dogs from CDV infection, but occasionally fails. In the present study, a wild type (wt) CDV, named XJ2, was isolated from a dead vaccinated dog. The hemagglutinin (H) gene of the XJ2 was amplified and analyzed for the molecular characteristics including N-glycosylation sites, phylogenesis, hydrophobicity and epitopes. The data indicated that XJ2 was a genetic variant strain of CDV. CDV-sero-negative dogs were inoculated intranasally with XJ2, developed severe clinical symptoms and died, suggesting high virulence.

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