数字农科院2.0

Comparative Mapping and 3 ' UTR SNP Detection of ANGPTL4 Gene in Beef Cattle

文献类型： 外文期刊

作者： Ma, Y.;Li, R. R.;Hou, F.;Zhang, Y. H.;Chen, H.;Ma, Y.;Xu, S. Z.;Cheng, N.

作者机构：

关键词： Cattle;ANGPTL4 gene;RH;SNP;IMF;China

期刊名称： JOURNAL OF ANIMAL AND VETERINARY ADVANCES

ISSN： 1680-5593

年卷期： 2011 年 10 卷 13 期

页码：

收录情况： SCI

摘要： Angiopoietin-like 4 (ANGPTL4), a member of the angiopoietin-like gene family, encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain which is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. ANGPTL4 is a serum hormone directly involved in regulating angiogenesis, lipid metabolism, glucose metabolism, cancer and metabolic diseases. In this study, Radiation Hybrid (RH) cloning board technique, PCR-SSCP and DNA sequencing methods were employed to map bovine ANGPTL4 gene and examine the single nucleotide polymorphisms (SNPs) at the 3'UTR of this gene in 281 cattle from seven breeds. Here, the bovine ANGPTL4 gene was located between the framework marker CA006 and DIK4204 on BTA7 with a map distance of 2.33 cR to the former and an interval of 8.54 cR to the latter. A novel mutation (NC_007305.3: g.C6640T) was revealed which constructed three genotypes (CC, CT and TT). This locus proved to be significantly associated with Average Daily Gain (ADG), Rib-eye Area (REA), Intramuscular Fat (IMF) (p<0.05) and Beef Performance Index (BPI) (p<0.01) in the analyzed populations. Meanwhile, individuals with genotype TT were significantly higher than those with CC in BPI, ADO and REA while it was reversed for genotype TT and CC in the IMF which proved that bovine ANGPTL4 gene had a positive effect on production traits, Hence, genotype TT and CC could be regarded as molecular markers for BPI, ADG and REA and IMF, respectively.

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