Changes in methylation of genomic DNA from chicken immune organs in response to H5N1 influenza virus infection
文献类型： 外文期刊
作者： Zhang, Y. H.;Meng, J. L.;Gao, Y.;Zhang, J. Y.;Niu, S. L.;Sun, B. X.;Zhao, Z. H.;Yu, X. Z.;Li, Y. B.;Guan, Y. T.
作者机构：
关键词： Avian influenza;H5N1;Immune organs;DNA methylation;F-MSAP
期刊名称： GENETICS AND MOLECULAR RESEARCH
ISSN： 1676-5680
年卷期： 2016 年 15 卷 3 期
页码：
收录情况： SCI
摘要： DNA methylation is an important epigenetic modification in eukaryotes, which plays a significant role in regulating gene expression. When the host is invaded by the influenza virus, gene expression is regulated via changes in DNA methylation levels or patterns, leading to the activation or suppression of relevant signaling pathways or networks, triggering a series of immune responses against viral invasion. Here, we investigated the changes in genomic DNA methylation in the immune organs of chicken infected with H5N1 influenza virus. Genome-wide DNA methylation levels in the spleen, thymus, and bursa of Fabricius of specific pathogen-free (SPF) chicken infected with the Guangdong (G-H5N1) and Anhui (A-H5N1) H5N1 strains, and water (control) were analyzed by fluorescence-labeled methylation-sensitive amplified polymorphism (F-MSAP). The results indicated that total DNA methylation levels did not differ between spleen genomic DNA in chicken treated with different viral strains and the control (P > 0.05). However, the total DNA methylation levels were significantly upregulated in the thymus (P < 0.01) and bursa (P < 0.05) of chicken in the A-H5N1 group compared to those in the G-H5N1 and control groups. These results provide a basis for the screening of avian influenza-resistance genes or methylation markers, analyzing the epigenetic regulation mechanisms of avian influenza, and performing selective breeding for disease resistance.
分类号：
- 相关文献
作者其他论文 更多>>
-
EFFECTS OF MAIZE (ZEA MAYS L.) INTERCROPPING WITH LEGUMES ON NITROUS OXIDE (N2O) EMISSIONS
作者：CHEN, J. S.;AMIN, A. S.;HAMANI, A. K. M.;WANG, G. S.;ZHANG, Y. Y.;LIU, K.;GAO, Y.
关键词：
-
Antagonistic Activity Against Rice Blast Disease And Elicitation Of Host-Defence Response Capability Of An Endophytic Streptomyces Albidoflavus Osilf-2
作者：Xu, T.;Zeng, J. R.;Zhu, Z. Y.;Zhu, Y. H.;Liu, X. M.;Ren, B.;Shi, L. M.;Zhou, Q.;Zhou, G. Y.;Zeng, X. D.;Gao, Y.;Yang, Y. Z.;Hu, X. C.
关键词：active metabolites; biological control; induced systemic resistance; Magnaporthe oryzae; rice endophyte; Streptomyces albidoflavus
-
Biological Characteristics Of A New A.ntibacterial Peptide And Its A ntibacterial Mechanisms Against Gram-Negative Bacteria
作者：Pei, Z.;Ying, X.;Tang, Y.;Kong, L.;Ma, H.;Liu, S.;Zhang, H.;Liu, L.;Wang, K.;Zhang, D.;Gao, Y.
关键词：antimicrobial peptide; biological characteristics; antibacterial mechanism; Gram-negative bacteria
-
Multi-Drug Resistance To Antibiotics And D.isinfectants In Campylobacter Isolates F rom Chicken And Poultry Meat In Jiangsu Province, China
作者：Zhou, Q.;Zhang, J.;Zhang, X.;Gao, Y.;Tang, M.
关键词：Campylobacter; chicken; multi-drug resistant; integron; gene cassette
-
Effect Of Timing And Ratio O.f Urea Fertilization On N -15 Recovery And Yield Of Cotton
作者：Sun, M.;Li, P. C.;Dong, H. L.;Wang, G. P.;Zheng, C. S.;Li, Y. B.;Zhao, X. H.;Liu, A. Z.;Liu, J. R.
关键词：urea; fertilization timing and ratio; seed cotton yield; N-15 recovery; cotton
-
Studies on the role of the SlNAC3 gene in regulating seed development in tomato (Solanum lycopersicum)
作者：Han, Q. Q.;Song, Y. Z.;Zhang, J. Y.;Liu, L. F.
关键词：
-
Dynamics of root water uptake and water use efficiency under alternate partial root-zone irrigation
作者：Li, C. X.;Zhou, X. G.;Sun, J. S.;Gao, Y.;Wang, H. Z.
关键词：Alternate furrow irrigation;Conventional furrow irrigation;Root water uptake;Maize;WUE