数字农科院2.0

‘Multiple and short-range’ cross-linking of dialdehyde carboxymethyl cellulose contributes to regulating the physicochemical property of collagen fibril

文献类型： 外文期刊

作者： Xiaoyue Yu;Chao Weng;Haiping Zhang;Zibo Qin;Yiliang Miao;Heng Wang;Shanbai Xiong;Jianhua Rong;Yang Hu

作者机构：

关键词： Collagen hydrogel;Cross-linking pattern;Dialdehyde carboxymethyl cellulose;Micro-structure;Schiff base

期刊名称： International Journal of Biological Macromolecules

ISSN： 0141-8130

年卷期： 2022 年 219.0 卷

页码：

收录情况： SCIE（2022版）

摘要： Collagen fibril hydrogel (CH), with controllable micro-structure, sufficient modifying sites and excellent biocompatibility, has received widely attention in the regulation of biomacromolecules. Herein, dialdehyde carboxymethyl cellulose (DCMC) in different -CHO contents and molecular weights demonstrated two types of cross-linking behaviors to CH, ‘limited and long-range’ or ‘multiple and short range’ cross-linking, corresponding to -CHO content ranged from 0 to 53 % and 53 to 90 %, respectively. In regard of structure, non-destroying effect of DCMC on collagen was supported by FT-IR and XRD analysis. CH cross-linked by DCMC (CH-DC) showed declining porosity and aggregating fibrils as -CHO content of DCMC rising. In regard of physicochemical properties, DCMC with >53 % -CHO strengthened the hydrophilicity, thermal stability and degradation resistance of CH-DC. Also, there was 110 % growth on gel strength, 86 Pa enhancements on storage modulus, and 4.6 times decrease on the swelling ratio of CH-DC. Results indicated that DCMC with 79 % -CHO remarkably improved the physicochemical properties of CH via developing sufficient Schiff-base bonds with collagen fibril in a short distance. This study distinguished two patterns of DCMC cross-linking from physicochemical view. In other words, DCMC is potential to meet the requirement of protein-based materials with different expectations by adjusting its -CHO content and molecular weight.

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