数字农科院2.0

Strain specificity of lactobacilli with promoted colonization by galactooligosaccharides administration in protecting intestinal barriers during Salmonella infection

文献类型： 外文期刊

作者： Wu, Yujun;Zhang, Xiangyu;Liu, Xiaoyi;Li, Yi;Han, Dandan;Pi, Yu;Whitmore, Melanie A.;Lu, Xingmiao;Zhang, Guolong;Zheng, Jinkai;Wang, Junjun

作者机构：

关键词： Galactooligosaccharides;Lactobacillus;Salmonella;Intestinal inflammation

期刊名称： JOURNAL OF ADVANCED RESEARCH

ISSN： 2090-1232

年卷期： 2024 年 56 卷

页码：

收录情况： SCIE（2024版）

摘要： Introduction: Galactooligosaccharides (GOS) are lactogenic prebiotics that exert health benefits by stimulating the growth of different Lactobacillus strains in the gastrointestinal (GI) tract. Objectives: This study aimed to investigate the mechanism of action of different GOS-enriched lactobacilli in intestinal health. Methods: Piglets and mice were supplemented with GOS to identify specific enrichment of Lactobacillus. The protective effects of individual GOS-enriched lactobacilli were investigated in Salmonella-infected mice. Macrophage depletion and transcriptome analysis were further performed to assess the involvement of macrophages and the underlying mechanisms of individual lactobacilli. An in vitro cell coculture system was also used to evaluate the anti-adhesive and anti-invasive activities of lactobacilli against Salmonella in epithelial cells. Results: GOS markedly increased the relative abundance of three lactobacilli including L. delbrueckii, L. johnsonii, and L. reuteri in both piglets and mice. Supplementation with GOS further alleviated Salmonella infection in mice. L. delbrueckii (ATCC (R) BAA 365TM), but not L. johnsonii or L. reuteri, enhanced propionate production in the intestinal tract and ameliorated Salmonella-induced intestinal inflammation and barrier dysfunction by suppressing the JAK2-STAT3 signaling and M1 macrophage polarization. L. johnsonii (BNCC 186110), on the other hand, inhibited Salmonella adhesion and invasion of epithelial cells through competitive exclusion. However, L. reuteri (BNCC 186135) failed to protect mice against Salmonella infection. Conclusion: GOS-enriched lactobacilli show a differential role in protecting against Salmonella-induced intestinal barrier dysfunction and inflammation. Our results provide novel insights into the mechanism of action of GOS and individual Lactobacillus strains in the control and prevention of intestinal inflammatory disorders. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article

分类号：

  • 相关文献

[1]Dietary organic acids ameliorate high stocking density stress-induced intestinal inflammation through the restoration of intestinal microbiota in broilers. Dong Dai,Guanghai Qi,Jing Wang,Haijun Zhang,Kai Qiu,Yanming Han,Yuanyuan Wu,Shugeng Wu. 2022

[2]Dietary Bacillus licheniformis shapes the foregut microbiota, improving nutrient digestibility and intestinal health in broiler chickens. Yunsheng Han,Xin Xu,Jiaxin Wang,Hongying Cai,Daojie Li,Hongwei Zhang,Peilong Yang,Kun Meng. 2023

[3]Metagenomic insights into the composition and function of the gut microbiota of mice infected with Toxoplasma gondii. Jin Xin Meng,Xin Yu Wei,Huanping Guo,Yu Chen,Wei Wang,Hong Li Geng,Xing Yang,Jiang Jiang,Xiao Xuan Zhang. 2023

[4]Algal oil alleviates antibiotic-induced intestinal inflammation by regulating gut microbiota and repairing intestinal barrier. Zhang H.,Xu Z.,Chen W.,Huang F.,Chen S.,Wang X.,Yang C.. 2023

[5]Synthesis and antibacterial activity of FST and its effects on inflammatory response and intestinal barrier function in mice infected with Escherichia coli O78. Ge W.,Li Z.,Yang Y.,Liu X.,Zhu Z.,Bai L.,Qin Z.,Xu X.,Li J.,Li S.. 2024

[6]Editorial: Functional feed additives and intestinal health in aquatic animals. Gang Yang,Zhen Zhang,Vikash Kumar. 2024

[7]Effect of dietary aspirin eugenol ester on the growth performance, antioxidant capacity, intestinal inflammation, and cecal microbiota of broilers under high stocking density. Haojie Zhang,Yi Zhang,Dongying Bai,Jiale Zhong,Xiaodi Hu,Ruilin Zhang,Wenrui Zhen,Koichi Ito,Bingkun Zhang,Yajun Yang,Jianyong Li,Yanbo Ma. 2024

[8]Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens. Dandan Ma,Minhong Zhang,Jinghai Feng. 2024

[9]Rosemary (Rosmarinus officinalis L.) polyphenols and inflammatory bowel diseases: Major phytochemicals, functional properties, and health effects. Lianhua Zhang,Jie Lu. 2024

[10]Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus. Zhang, Shunfen,Zhong, Ruqing,Zhou, Miao,Li, Kai,Lv, Huiyuan,Wang, Huixin,Xu, Ye,Liu, Dadan,Ma, Qiugang,Chen, Liang,Zhang, Hongfu. 2025

[11]A Novel Synbiotic Protects Against DSS-Induced Colitis in Mice via Anti-inflammatory and Microbiota-Balancing Properties. Yang, Yong,Qiao, Yuyu,Liu, Ge,Chen, Weihao,Zhang, Ting,Liu, Jing,Fan, Weiping,Tong, Mingwei. 2024

[12]Baicalin alleviates intestinal inflammation and microbial disturbances by regulating Th17/Treg balance and enhancing Lactobacillus colonization in piglets. Shunfen Zhang,Chengzeng Luo,Kai Li,Junhong Wang,Huixin Wang,Ruqing Zhong,Liang Chen,Qiugang Ma,Hongfu Zhang. 2024

[13]Protective effect of a newly probiotic Lactobacillus reuteri LY2-2 on DSS-induced colitis. Yang, Yong,Qiao, Yuyu,Liu, Ge,Yi, Gaoqin,Liu, Hongli,Zhang, Ting,Tong, Mingwei. 2025

[14]Dietary Fagopyrum dibotrys Extract Supplementation: Impacts on Growth Performance, Immune Response, Intestinal Morphology, and Microbial Community in Broiler Chickens Infected with Escherichia coli O157. Jiang Chen,Gaoxiang Ai,Pingwen Xiong,Wenjing Song,Guohua Liu,Qipeng Wei,Xiaolian Chen,Zhiheng Zou,Qiongli Song. 2025

[15]Pectic polysaccharides from unripe and mature kiwifruit alleviate ulcerative colitis by modulating gut microbiota and restoring the intestinal barrier. Kai Xin Jiang,Jin Lei Geng,Qin Yuan,Jie Li,Wen Liu,Hong Yan Liu,Yi Chen Hu,Liang Zou,Shengpeng Wang,Ding Tao Wu. 2025

[16]Dietary Mannan-Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF-κB Signaling. Lu, Yutong,Sun, Yiwei,Cai, Kun,He, Pingli,Lin, Gang,Qi, Zengkai,Liu, Hu,Yan, Junshu,Ma, Ning. 2025

[17]Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway. Ying Chen,Chengzeng Luo,Zhaohan Zhan,Shuo Liu,Chunran Teng,Ruixiao Mao,Shunfen Zhang,Xunbozan Zhang,Qingshi Meng,Ruqing Zhong,Liang Chen,Hongfu Zhang. 2025

[18]Antioxidative activity of lactic acid bacteria in yogurt. Zhang, Shuwen,Liu, Lu,Su, Yanling,Li, Hongjuan,Sun, Qi,Liang, Xiao,Lv, Jiaping. 2011

[19]Construction of recombinant lactobacilli expressing the core neutralizing epitope (COE) of porcine epidemic diarrhea virus and a fusion protein consisting of COE and Escherichia coli heat-labile enterotoxin B, and comparison of the immune responses by orogastric immunization. Ge, Jun-Wei,Li, Yi-Jing,Liu, Di-Qiu.

[20]Effect of Different Fermentation Parameters on Lactic Acid Production from Kitchen Waste by Lactobacillus TY50. Wang, Q. -H.,Ma, H. -Z.,Wang, X. -M.,Wang, X. -Q.. 2011

作者其他论文 更多>>