数字农科院2.0

Chlorella's transport inhibition: A powerful defense against high ammonium stress

文献类型： 外文期刊

作者： Xu, Lihe;Chen, Li;Jiang, Longxing;Zhang, Jingni;Wu, Peike;Wang, Wenguo

作者机构：

关键词： C. sorokiniana;High NH 4+concentration tolerance;Uptake of NH 4+;Transport inhibition;NH 4+-rich wastewater

期刊名称： ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ISSN： 0147-6513

年卷期： 2025 年 290 卷

页码：

收录情况： SCIE（2025版）

摘要： Ammonium (NH4+) is a primary nitrogen source for many species, yet NH4+-rich wastewater presents a substantial risk to environment. Chlorella sorokiniana is widely recognized for wastewater treatment. The development of high NH4+ tolerant strains has the potential to significantly enhance wastewater treatment efficiency and reduce treatment costs. This study reports the identification of a C. sorokiniana strain designated hact (high ammonium concentration tolerance). This strain demonstrates a remarkable tolerance to NH4+ (1000 mg/L). Integrative analyses of physiology, metabolomics, and transcriptomics demonstrated that transport inhibition is the principal resistance mechanism against high NH4+ stress in C. sorokiniana. Notably, under elevated NH4+ conditions, the hact strain maintained robust intracellular homeostasis. In contrast, the wild-type (WT) strain exhibited suppressed metabolic activity, reactive oxygen species (ROS), and an excess of detrimental metabolites such as amines. This research enriches our understanding of microalgal molecular responses to high NH4+ stress, paving the way for the development of engineered optimization strategies for microalgal bioremediation systems treating NH4+-rich wastewater.

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