数字农科院2.0

Modulation of pectin on intestinal barrier function via changes in microbial functional potential and bile acid metabolism

文献类型： 外文期刊

作者： Yin C.;Wen X.;Dang G.;Zhong R.;Meng Q.;Feng X.;Liu L.;Wu S.;He J.;Chen L.;Zhang H.

作者机构：

关键词： bile acid;ileal microbiota;intestinal health;pectin

期刊名称： Journal of Nutritional Biochemistry

ISSN： 0955-2863

年卷期： 2024 年 124 卷

页码：

收录情况： SCIE（2024版）

摘要： Weaning is one of the major factors that cause stress and intestinal infection in infants and in young animals due to an immature intestine and not fully developed immune functions. Pectin (PEC), a prebiotic polysaccharide, has attracted considerable attention in intestinal epithelial signaling and function via modulation of the microbial community. A total of 16 weaned piglets (21-d-old) were randomly assigned into two groups: control group and PEC group. Supplementation of 5% pectin improved intestinal mucosal barrier function by modulating the composition of the bile acid pool in piglets. Specifically, piglets in PEC group had less serum D-lactate content and alkaline phosphatase activity. In the ileum, dietary pectin increased the number of crypt PAS/AB-positive goblet cells and the mRNA expressions of MUC2, ZO-1, and Occludin. Piglets in PEC group displayed a decreased abundance of Enterococcus (2.71 vs. 65.92%), but the abundances of Lactobacillus (30.80 vs. 7.93%), Streptococcus (21.41 vs. 14.81%), and Clostridium_sensu_stricto_1 (28.34 vs. 0.01%) were increased. Elevated concentrations of bile acids especially hyocholic acid species (HCAs) including HCA, HDCA, and THDCA were also observed. Besides, correlation analysis revealed that dietary pectin supplementation may have beneficial effects through stimulation of the crosstalk between gut microbes and bile acid synthesis within the enterohepatic circulation. Thus, dietary pectin supplementation exhibited a further positive effect on the healthy growth and development of weaned piglets. These findings suggest pectin supplementation as the prebiotic is beneficial for gut health and improvement of weaned stress via regulating microbiota and bile acid metabolism. © 2023 Elsevier Inc.

分类号：

  • 相关文献

[1]Supplementation of exogenous bile acids improve antitrichomonal activity and enhance intestinal health in pigeon (Columba livia). Hui Ma,Shixiong Bian,Pengmin Han,Yunlei Li,Aixin Ni,Ran Zhang,Pingzhuang Ge,Yuanmei Wang,Jinmeng Zhao,Yunhe Zong,Jingwei Yuan,Yanyan Sun,Jilan Chen. 2023

[2]Hydroxytyrosol Alleviates Intestinal Oxidative Stress by Regulating Bile Acid Metabolism in a Piglet Model. Xiaobin Wen,Fan Wan,Ruqing Zhong,Liang Chen,Hongfu Zhang. 2024

[3]Effects of Increasing Stocking Density on the Performance and Ileal Microbiota of Broilers. Li Y.,Xing S.,Wang X.,Li X.,Zhang M.,Feng J.. 2022

[4]Chemically Protected Sodium Butyrate Improves Growth Performance and Early Development and Function of Small Intestine in Broilers as One Effective Substitute for Antibiotics. Huaibao Zhao,Hai Bai,Fuli Deng,Ruqing Zhong,Lei Liu,Liang Chen,Hongfu Zhang. 2022

[5]Aspirin eugenol ester affects ileal barrier function, inflammatory response and microbiota in broilers under lipopolysaccharide-induced immune stress conditions. Ruilin Zhang,Dongying Bai,Wenrui Zhen,Xiaodi Hu,Haojie Zhang,Jiale Zhong,Yi Zhang,Koichi Ito,Bingkun Zhang,Yajun Yang,Jianyong Li,Yanbo Ma. 2024

[6]Effects Of Dietary Pectin On T.he Profile And Transport O f Intestinal Bile Acids In Young Pigs. Fang, W, Zhang, L, Meng, QS, Wu, WD, Lee, YK, Xie, JJ, Zhang, HF. 2018

[7]The Effect of Duck Bile Acid Extract on the Fecal Microbiota, Short Chain Fatty Acids, Fat Digestibility and Blood Biochemical Indices in Cats. Bing Han,Peng Zhao,Shukun Liang,Zhenlong Wang,Hui Tao,Xiumin Wang,Jie Liu,Jinquan Wang. 2023

[8]Exposure to High Aerial Ammonia Causes Hindgut Dysbiotic Microbiota and Alterations of Microbiota-Derived Metabolites in Growing Pigs. Shanlong Tang,Ruqing Zhong,Chang Yin,Dan Su,Jingjing Xie,Liang Chen,Lei Liu,Hongfu Zhang. 2021

[9]Impact Of Clinical Use Of P.arenteral Lipid Emulsions On B ile Acid Metabolism And Composition In Neonatal Piglets. Lavallee, CM, Lim, DW, Wizzard, PR, Mazurak, VC, Mi, S, Curtis, JM, Willing, BP, Yap, JY, Wales, PW, Turner, JM. 2019

[10]Screening for potential warning biomarkers in cows with ketosis based on host–microbiota co-metabolism analysis. Zhenlong Du,Zhengzhong Luo,Yixin Huang,Tao Zhou,Li Ma,Dan Wu,Xueping Yao,Liuhong Shen,Shumin Yu,Kang Yong,Zuoting Yan,Suizhong Cao. 2024

[11]Decoding the role of the intestinal epithelium in hepatitis E virus infection using a human organoid prototype of “gut-liver” axis. Kuan Liu,Yang Wang,Jiangrong Zhou,Joy Joàn van der Meij,Luc J.W. van der Laan,Pengfei Li,Qiuwei Pan. 2025

[12]Lard reduces obesity in mice compared with corn oil and canola oil via modulating gut microbiota and bile acid metabolism. Li, Wusun,Wu, Weida,Zhang, Yuhui,Tang, Xiaoyan,Zheng, Xin,Huang, Xinyuan. 2025

[13]Dihydroquercetin attenuated Prevotella copri-caused intestinal injury by modulating gut microbiota and bile acids in weaned piglets. Long Wang,Ruizhi Hu,Siqi Ma,Xizi Yang,Jiatai Gong,Hongkun Xiang,Mingkun Shi,Xupeng Yuan,Liang Chen,Hongfu Zhang,Bie Tan,Xi He,Jianhua He,Shusong Wu. 2025

[14]Bile acid synthesis dysregulation in liver diseases promotes ectopic expansion of oral streptococci in the intestine. Yugui Wang,Wenjie Mu,Jian Guan,Pingping Ma,Yaqi Li,Ying Zhang,Wenjun Zhu,Yu Zhou,Yang Zou,Tongxu Zeng,Jian Zhou,Xiaoqi Lin,Xuehua Yan,Wenjuan Shi,Xiaola Guo,Xing Quan Zhu,Xuepeng Cai,Yan Sun,Aijiang Guo,Shuai Wang. 2025

[15]Hyocholic Acid Species as the Key Modulator for Cecal Epithelial Homeostasis in Low-Birth-Weight Piglets. Chang Yin,Xuan Liu,Wei Fang,Qingshi Meng,Xiaohui Feng,Weidong Zhang,Guoqi Dang,Ruqing Zhong,Liang Chen,Zirong Wang,Hongfu Zhang. 2025

[16]Effects of glucose oxidase on the growth performance, serum parameters and faecal microflora of piglets. Tang, H.,Yao, B.,Gao, X.,Yang, P.,Zhang, G.,Wang, Z.,Tang, H.,Zhang, G.. 2016

[17]Intestinal dysbiosis in nonalcoholic fatty liver disease (NAFLD): focusing on the gut-liver axis. Han, Hui,Jiang, Yi,Wang, Mengyu,Melaku, Mebratu,Liu, Lei,Zhao, Yong,Everaert, Nadia,Yi, Bao,Zhang, Hongfu. 2021

[18]Yeast-derived mannan-rich fraction as an alternative for zinc oxide to alleviate diarrhea incidence and improve growth performance in weaned pigs. G. Zhang,J. B. Zhao,W. X. Dong,X. M. Song,G. Lin,D. F. Li,S. Zhang. 2021

[19]Dietary Supplementation of a New Probiotic Compound Improves the Growth Performance and Health of Broilers by Altering the Composition of Cecal Microflora. Kai Qiu,Xiaocui Wang,Haijun Zhang,Jing Wang,Guanghai Qi,Shugeng Wu. 2022

[20]Long-term chemically protected sodium butyrate supplementation in broilers as an antibiotic alternative to dynamically modulate gut microbiota. F. Wan,F. L. Deng,L. Chen,R. Q. Zhong,M. Y. Wang,B. Yi,L. Liu,H. B. Zhao,H. F. Zhang. 2022

作者其他论文 更多>>