数字农科院2.0

Self-assembled tannic acid-prodigiosin nanoparticles for synergistic MRSA-infected wound healing and flap repair

文献类型： 外文期刊

作者： Liu, Liuying;Yin, Caiyun;Xiong, Xiang;Yang, Zhaozhi;Chang, Li;Tang, Dongying;Chen, Meiwan;Liu, Bin

作者机构：

关键词： Prodigiosin;Self-assembly nanoparticles;MRSA infection;Tissues repair;NF-kappa B signaling

期刊名称： CHEMICAL ENGINEERING JOURNAL

ISSN： 1385-8947

年卷期： 2025 年 528 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Persistent redox imbalance and chronic inflammation seriously limited healing rate of infected wound and flap in plastic surgery. To address this issue, we developed carrier-free Tannic Acid and Prodigiosin nanoparticles (TA@PG NPs) through synergistic hydrophobic interaction hydrogen bonding and electrostatic-driven molecular self-assembly. The nanoparticles demonstrated strong capability against methicillin-resistant Staphylococcus aureus (MRSA) through disrupting membrane and suppressing ATP synthesis. In vitro analyses validated multifunctional therapeutic capabilities, including reactive oxygen species (ROS) scavenging, anti-inflammation and promotion of Hunan Umbilical Vein Endothelial Cells (HUVECs) migration and angiogenesis. In a murine model of MRSA-infected ischemic flap, treatment with TA@PG NPs caused a marked decrease in the flap necrosis rate by attenuating the inflammatory response and promoting angiogenesis via inhibition of the Nuclear factor kappa-B (NF-kappa B)/Matrix metallopeptidase 9 (MMP-9) signaling Cascade. In summary, these results suggest that TA@PG NPs are a versatile therapeutic drug for flap salvage that synergistically combines microbial eradication, restoration of redox homeostasis, and microvascular reconstruction to overcome the dual challenges of infection-induced necrosis and ischemia during damaged tissue repair.

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