Contrasting pathogenicity of an epizootic hemorrhagic disease virus serotype 7 isolate: high virulence in IFNAR(-/-) mice versus a negligible role of sheep in EHDV-7 epidemiology
文献类型： 外文期刊
作者： Junyong Guan;Yinglin Qi;Yingran Huang;Ran Shao;Dong Zhou;Cankun Xi;Xin Yin
作者机构：
关键词： EHDV
期刊名称： Archives of Virology
ISSN： 0304-8608
年卷期： 2025 年 170 卷 10 期
页码：
收录情况： SCIE（2025版）
摘要： Epizootic hemorrhagic disease virus (EHDV) causes severe disease in ruminants. We assessed the pathogenicity of the Chinese EHDV-7 isolate YN09 in mice lacking the type I interferon receptor and in sheep. In mice, YN09 infection resulted in 100% mortality, with histopathological lesions, viral replication, and immunoreactivity in multiple organs. In sheep, infection with this virus resulted in transient RNAemia and low-level production of neutralizing antibodies, but no clinical signs or viremia were observed. These findings contrast YN09’s high murine virulence with sheep resistance, suggesting that sheep play a negligible role in EHDV-7 transmission in China. Further studies of other natural hosts are needed in order to understand the ecology of this EHDV-7 strain.
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