数字农科院2.0

Curcumin Alleviates HMGB1-Mediated Inflammation Through the Signaling Pathway of TLR2-NF-κB in Bovine Ovarian Granulosa Cells

文献类型： 外文期刊

作者： Siqi Liu;Yingying Xie;Lei Wang;Jingyan Zhang;Xiaoliang Chen;Xiaowei Feng;Junyan Wang;Kang Zhang;Jianxi Li

作者机构：

关键词： bovine ovarian granulosa cells;curcumin;HMGB1;inflammation;TLR2

期刊名称： International Journal of Molecular Sciences

ISSN： 1422-0067

年卷期： 2025 年 26 卷 18 期

页码：

收录情况： SCIE（2025版）

摘要： Curcumin, the principal bioactive compound derived from turmeric, possesses a wide range of therapeutic properties such as anti-inflammatory, antioxidant, and wound-healing properties. Recent studies suggest that curcumin may alleviate HMGB1-mediated inflammation in ovarian cells. However, its role in modulating dysfunction in HMGB1-driven ovarian granulosa cells (OGCs) remains to be elucidated. In the present study, curcumin suppresses the HMGB1-induced overexpression of toll-like receptor 2 (TLR2) and ovulation-related factors such as EGFR, VEGF, STAR, and TIMP1/2 genes. Additionally, the elevated levels of TLR2, TLR1, TLR6, and phospho-NF-κB p65 proteins were significantly inhibited by curcumin. Further mechanistic analysis reveals that the interaction between HMGB1 and the TLR1-TLR2/TLR6 complex, as well as phospho-NF-κB p65, was restrained. This resulted in the suppression of the pro-inflammatory cytokine IL-6 production and the alleviation of the HMGB1-induced inflammation response in OGCs. Collectively, our findings demonstrate that curcumin modulates the upregulation of ovulation-related genes and pro-inflammatory cytokines in OGCs by inhibiting the TLR2-NF-κB pathway, providing a mechanistic basis for its potential application as a therapeutic agent against OGC inflammation.

分类号：

  • 相关文献

[1]High mobility group box-1 regulates expression of EGFR, VEGF, StAR and TIMP1/2 in bovine granulosa cells through a mechanism involving TLR2/NF-κB. Yingying Xie,Kang Zhang,Jingyan Zhang,Kai Zhang,Xuequan Hu,Lei Wang,Xuezhi Wang,Jianxi Li. 2022

[2]Curcumin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice Through Regulating Gut Microbiota. Guo, Xiaoxuan,Xu, Ye,Geng, Ruixuan,Qiu, Jing,He, Xiaoyun. 2022

[3]辐照致弱日本血吸虫尾蚴/童虫中高迁移率族蛋白(SjHMGB1)功能的初步研究. 李丹丹,刘群,马丽贞,段明明,艾敏,史晓娜,塔娜,苑纯秀,冯新港. 2015

[4]牛分枝杆菌重组蛋白TB10.4对RAW264.7细胞TLR2表达和分布的影响. 刘淑清,李平俊,鑫婷,侯绍华,朱鸿飞,贾红. 2015

[5]TLR2介导鸡毒支原体脂质相关膜蛋白诱导DF-1细胞表达IL-1β的研究. 陈莹,汪洋,于颖,李媛,王琪,邵家日,王显兵,周长平,李继昌,辛九庆. 2017

[6]五指山小型猪近交系主动脉内皮细胞体外培养模型的建立和TLR2介导炎症相关因子的表达. 王攀,陶晓莉,沈祖楠,李和刚,潘杰,牟玉莲,李奎. 2012

[7]Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-beta. Huan, Chang-chao,Wang, Hua-xia,Sheng, Xiang-xiang,Wang, Rui,Wang, Xin,Fan, Hong-jie,Mao, Xiang,Liao, Ying,Liu, Qin-fang,Tong, Guang-zhi,Ding, Chan,Mao, Xiang,Wu, Jia-qiang. 2016

[8]Newcastle Disease Virus Infection Triggers H.mgb1 Release To Promote T he Inflammatory Response. Qu, YR, Zhan, Y, Yang, S, Ren, SH, Qiu, XS, Rehamn, ZU, Tan, L, Sun, YJ, Meng, CC, Song, CP, Yu, SQ, Ding, C. 2018

[9]Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. Liu, Shuqing,Jia, Hong,Hou, Shaohua,Zhang, Gaimei,Xin, Ting,Yuan, Weifeng,Guo, Xiaoyu,Li, Ming,Wu, Jing,Zhu, Hongfei,Li, Hegang,Li, Hegang,Gao, Xintao. 2014

[10]Toll-Like Receptor 2 Gene Polymorphism and its Relationship with SCS in Dairy Cattle. Zhang, L. P.,Li, H. D.,Li, J. Y.,Gao, X.,Chen, J. B.,Ren, H. Y.,Xu, S. Z.,Gan, Q. F.,Wang, X. P.,Xu, S. Z.,Ma, T. H.. 2009

[11]Cysticercus pisiformis-derived novel-miR1 targets TLR2 to inhibit the immune response in rabbits. Guoliang Chen,Guiting Pu,Liqun Wang,Yanping Li,Tingli Liu,Hong Li,Shaohua Zhang,Xuelin Wang,Xiaolei Liu,Xuenong Luo. 2023

[12]Curcumin As An Alternative Epigenetic M.odulator: Mechanism Of Action A nd Potential Effects. Khan, Muhammad Sajjad,Javed, Aroosa,Yang, Chengjian,Yang, Chengjian,Rehman, Muhammad Saif-ur,Nawaz, Ayesha,Faiz-ul Hassan,Faiz-ul Hassan,Faiz-ul Hassan,Ali, Muhammad Amjad. 2019

[13]Effects of Curcumin on Buffalo Embryonic Development In Vitro. Shang, Jiang-Hua,Yang, Chun-Yan,Zheng, Hai-Ying,Jing-Qin,Wang, Jian,Huang, Fen-Xiang,Yang, Bing-Zhuang,Liang, Xiang-Wei. 2013

[14]Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. He, Xi-Jun,He, Xi-Jun,Uchida, Kazuyuki,Nakayama, Hiroyuki,Megumi, Chiaki,Tsuge, Nobuaki. 2015

[15]Natural oil bodies from typical oilseeds: Structural characterization and their potentials as natural delivery system for curcumin. Shan Zhang,Hongjian Chen,Fang Geng,Dengfeng Peng,Bijun Xie,Zhida Sun,Yashu Chen,Qianchun Deng. 2022

[16]Curcumin mitigates Cryptosporidium parvum infection through modulation of gut microbiota and innate immune-related genes in immunosuppressed neonatal mice. Sajid Ur Rahman,Keke Zhou,Sha Sha Zhou,Tiancong Sun,Rongsheng Mi,Yan Huang,Xiangan Han,Haiyan Gong,Zhaoguo Chen. 2022

[17]Identification of curcumin as a potential α‐glucosidase and dipeptidyl‐peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation. Wanxiu Cao,Xin Chen,Yaoxian Chin,Jinkai Zheng,Phaik Eem Lim,Changhu Xue,Qingjuan Tang. 2021

[18]Curcumin Affects Gastric Cancer Cell Migration, Invasion And Cytoskeletal Remodeling Through Gli1-Beta-Catenin. Zhang, X, Zhang, CL, Ren, ZH, Zhang, FF, Xu, JY, Zhang, X, Zheng, HX. 2020

[19]Dietary factors in nonalcoholic fatty liver disease: impacts on human and animal health - a review. Yeung, Andy Wai Kan,Ksepka, Natalia,Matin, Maima,Wang, Dongdong,Souto, Eliana B.,Stoyanov, Jivko,Echeverria, Javier,Tewari, Devesh,Horbanczuk, Jaroslaw Olav,Lucarini, Massimo,Durazzo, Alessandra,Marchewka, Joanna,Pirgozliev, Vasil,Gan, Ren-You,Tzvetkov, Nikolay T.,Wysocki, Kamil,Matin, Farhan Bin,Litvinova, Olena,Bishayee, Anupam,Devkota, Hari Prasad,El-Demerdash, Amr,Brncic, Mladen,Santini, Antonello,Horbanczuk, Olaf. K.,Mickael, Michel-Edwar,Lawinski, Michal,Das, Niranjan,Siddiquea, Bodrun Naher,Hrg, Dalibor,Atanasov, Atanas G.. 2023

[20]Utilization of polysaccharide-based high internal phase emulsion for nutraceutical encapsulation and 3D printing: Reinforcement of curcumin stability and bioaccessibility. Xueqing Li,Liuping Fan,Jinwei Li. 2023

作者其他论文 更多>>