数字农科院2.0

An inactivated vaccine based on artificial non-pathogenic fowl adenovirus 4 protects chickens against hepatitis-hydropericardium syndrome

文献类型： 外文期刊

作者： Zhang Y.; Liu A.; Cui H.; Qi X.; Liu C.; Zhang Y.; Li K.; Gao L.; Wang X.; Pan Q.; Gao Y.

作者机构：

关键词： adenovirus vaccine; inactivated hypervirulent fowl adenovirus 4 vaccine; inactivated vaccine; neutralizing antibody; unclassified drug; vaccine adjuvant; virus DNA; virus RNA; inactivated vaccine; virus vaccine; adenovirus infection; animal cell; animal experiment; animal tissue; antibody titer; antigen specificity; Article; blood sampling; controlled study; hepatitis hydropericardium syndrome; histopathology; Leghorn chicken; lethal dose; male; nonhuman; plaque forming unit; poultry; vaccination; vaccine immunogenicity; virus hepatitis; virus load; virus recombinant; virus virulence; adenovirus infection; animal; Aviadenovirus; bird disease; chicken; hepatitis A; immunology; veterinary medicine; Adenoviridae Infections; Animals; Aviadenovirus; Chickens; Hepatitis A; Poultry Diseases; Vaccines; Inactivated; Viral Vaccines

期刊名称： Veterinary Microbiology

ISSN： 0378-1135

年卷期： 2022 年 264 卷

页码：

收录情况： SCIE（2022版）

摘要： Hepatitis-hydropericardium syndrome (HHS) in birds is mainly caused by virulent fowl adenovirus 4 (FAdV-4). A novel genotype, hypervirulent FAdV-4, emerged in 2015 with a high mortality rate ranging from 30 % to 100 % in chickens. Vaccination is an economically feasible method to control HHS. Although there have been various reports of inactivated vaccines from virulent wild-type FAdV-4 against HHS, biosafety threats of inactivated vaccines from potential pathogenic components have been presented to the poultry industry, and safer vaccines are urgently needed. A non-pathogenic recombinant FAdV-4 strain, designated as rHN20, was generated based on the hypervirulent strain in our previous study. Here, we developed a novel inactivated oil-adjuvanted vaccine derived from rHN20 strain and evaluated its immunogenicity in specific-pathogen-free chickens. Chickens subcutaneously or intramuscularly immunized with the inactivated vaccine produced high titers of neutralizing antibodies and were protected from a lethal dose of virulent wild-type FAdV-4 challenge. Collectively, an inactivated vaccine was developed, which was capable of providing full protection for chickens against HHS, and significantly reduced the potential biosafety threats. © 2021 Elsevier B.V.

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