数字农科院2.0

Regulation of rna n6-methyladenosine modification and its emerging roles in skeletal muscle development

文献类型： 外文期刊

作者： Li Jiju;Pei Yangli;Zhou Rong;Tang Zhonglin;Yang Yalan

作者机构：

关键词： Development; Myogenesis; RNA N6-methyladenosine; Skeletal muscle

期刊名称： International Journal of Biological Sciences

ISSN： 1449-2288

年卷期： 2021 年 17 卷 7 期

页码：

收录情况： JCR（2021版）

摘要： N6-methyladenosine (m6A) is one of the most widespread and highly conserved chemical modifications in cellular RNAs of eukaryotic genomes. Owing to the development of high-throughput m6 A sequencing, the functions and mechanisms of m6A modification in development and diseases have been revealed. Recent studies have shown that RNA m6 A methylation plays a critical role in skeletal muscle development, which regulates myoblast proliferation and differentiation, and muscle regeneration. Exploration of the functions of m6A modification and its regulators provides a deeper understanding of the regulatory mechanisms underlying skeletal muscle development. In the present review, we aim to summarize recent breakthroughs concerning the global landscape of m6A modification in mammals and examine the biological functions and mechanisms of enzymes regulating m6A RNA methylation. We describe the interplay between m6A and other epigenetic modifications and highlight the regulatory roles of m6A in development, especially that of skeletal muscle. m6A and its regulators are expected to be targets for the treatment of human muscle-related diseases and novel epigenetic markers for animal breeding in meat production. © The author(s).

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