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Tyrosol inhibits NF-κB pathway in the treatment of enterotoxigenic Escherichia coli-induced diarrhea in mice

文献类型： 外文期刊

作者： Fazheng Yu;Jian Guo;Hong lin Ren;Shiying Lu;Zhaoqi He;Jiang Chang;Xueyu Hu;Ruoran Shi;Yuanyuan Jin;Yansong Li;Zengshan Liu;Xiaoxu Wang;Pan Hu

作者机构：

关键词： Bacterial diarrhea;Enterotoxigenic Escherichia coli;NF-κB;Tyrosol

期刊名称： Microbial Pathogenesis

ISSN： 0882-4010

年卷期： 2023 年 176 卷

页码：

收录情况： SCIE（2023版）

摘要： Tyrosol is one of the main polyphenol compounds in white wine and extra virgin olive oil (EVOO), which plays an antioxidant and anti-inflammatory role in vitro. In the present study, we investigated the possible anti-inflammatory mechanism of tyrosol in Escherichia coli (ETEC)-induced diarrhea in mice. ICR mice were randomly divided into control group, ETEC group, and ETEC + Tyrosol group with 10 mice in each group. In addition to the control group, a bacterial diarrhea model was induced in mice by continuous administration of 0.2 ml × 109 CFU/ml ETEC. After 7 days, the ETEC + Tyrosol group was given tyrosol (20 mg/kg) once a day by gavage, during which the body weight of mice and the degree of diarrhea were measured daily. On the 15th day, all animals in this experiment were sacrificed, colon tissue was collected, and colon length was recorded. Our results indicate that tyrosol significantly attenuated the extent of ETEC-induced diarrhea, including inhibition of pro-inflammatory cytokine, repair of the intestinal epithelial mechanical barrier, and significant inhibition of NF-κB activation. This finding is helpful for the development and further application of tyrosol in the treatment of diarrhea.

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