数字农科院2.0

Plant secondary metabolites against biotic stresses for sustainable crop protection

文献类型： 外文期刊

作者： Tanzim Jahan;Md Nurul Huda;Kaixuan Zhang;Yuqi He;Dili Lai;Namraj Dhami;Muriel Quinet;Md Arfan Ali;Ivan Kreft;Sun Hee Woo;Milen I. Georgiev;Alisdair R. Fernie;Meiliang Zhou

作者机构：

关键词： Biotic stress;CRISPR/Cas9;Metabolic engineering;RNAi;Secondary metabolite;Transcription factor

期刊名称： Biotechnology Advances

ISSN： 0734-9750

年卷期： 2025 年 79 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Sustainable agriculture practices are indispensable for achieving a hunger-free world, especially as the global population continues to expand. Biotic stresses, such as pathogens, insects, and pests, severely threaten global food security and crop productivity. Traditional chemical pesticides, while effective, can lead to environmental degradation and increase pest resistance over time. Plant-derived natural products such as secondary metabolites like alkaloids, terpenoids, phenolics, and phytoalexins offer promising alternatives due to their ability to enhance plant immunity and inhibit pest activity. Recent advances in molecular biology and biotechnology have improved our understanding of how these natural compounds function at the cellular level, activating specific plant defense through complex biochemical pathways regulated by various transcription factors (TFs) such as MYB, WRKY, bHLH, bZIP, NAC, and AP2/ERF. Advancements in multi-omics approaches, including genomics, transcriptomics, proteomics, and metabolomics, have significantly improved the understanding of the regulatory networks that govern PSM synthesis. These integrative approaches have led to the discovery of novel insights into plant responses to biotic stresses, identifying key regulatory genes and pathways involved in plant defense. Advanced technologies like CRISPR/Cas9-mediated gene editing allow precise manipulation of PSM pathways, further enhancing plant resistance. Understanding the complex interaction between PSMs, TFs, and biotic stress responses not only advances our knowledge of plant biology but also provides feasible strategies for developing crops with improved resistance to pests and diseases, contributing to sustainable agriculture and food security. This review emphasizes the crucial role of PSMs, their biosynthetic pathways, the regulatory influence of TFs, and their potential applications in enhancing plant defense and sustainability. It also highlights the astounding potential of multi-omics approaches to discover gene functions and the metabolic engineering of genes associated with secondary metabolite biosynthesis. Taken together, this review provides new insights into research opportunities for enhancing biotic stress tolerance in crops through utilizing plant secondary metabolites.

分类号：

  • 相关文献

[1]Global transcriptome and gene regulation network for secondary metabolite biosynthesis of tea plant (Camellia sinensis). Li, Chun-Fang,Wang, Xin-Chao,Yao, Ming-Zhe,Chen, Liang,Yang, Ya-Jun,Zhu, Yan,Yu, Yao,Zhao, Qiong-Yi,Li, Xuan,Wang, Sheng-Jun,Luo, Da. 2015

[2]低纤维素酶背景里氏木霉菌株的构建和应用. 刘杜娟,黄火清,苏小运. 2020

[3]Genome-Wide Identification and Characterization of the WRKY Gene Family in Cucurbita maxima. Qin Zhou,Ziqing Guo,Xiaojun Zhou,Lei Zhou,Duanhua Wang,Kailiang Bo,Pu Zhu. 2023

[4]Enhancement of abscisic acid biosynthesis in Saccharomyces cerevisiae via multidimensional engineering. Xiaofei Song,Jianze Zhang,Xikai Wang,Haonan Yu,Nuo Xu,Longyu Cao,Xiuwen Zhong,Puhong Yi,Jie Sun,Kun Wang,Chao Feng,Weixia Wang,Tingheng Zhu. 2024

[5]Engineering plant hosts for high-efficiency accumulation of flavonoids: Advances, challenges and perspectives. Yameng Xu,Xiaoyang Ge,Yongkun Lv,Zhaoen Yang,Fuguang Li,Zuoren Yang. 2025

[6]CRISPR/Cas9-mediated editing of the melanization gene ebony in the 28-spotted ladybeetle, Henosepilachna vigintioctopunctata. Chen, Shimin,Ruan, Yalin,Li, Zhaoyang,Zhou, Chuqiao,Chen, Qi,Zhou, Xuguo,Zhang, Youjun,Yang, Chunxiao,Pan, Huipeng. 2025

[7]Traversing the heat-A review on heat stress untangling the modern approaches in soybean (Glycine max. L). Aiman Sana,Aitezaz A.A. Shahani,Ullah Ihsan,Rashida Hameed,Adeel Abbas,Sidra Balooch,Faisal Summiya,Usman Zulfiqar,PV Vara Prasad,Ivica Djalovic. 2025

[8]Protein-DNA interactions in the promoter region of the gene encoding diapause hormone and pheromone biosynthesis activating neuropeptide of the cotton bollworm, Helicoverpa armigera. Hong, B,Zhang, ZF,Tang, SM,Yi, YZ,Zhang, TY,Xu, WH.

[9]Allelopathic effects of wheat extracts and DIMBOA on weeds. Zhao, Y.,Dong, F. S.,Liu, X. G.,Yao, J. R.,Hurle, K..

[10]Interspecific Hybridization between Ganoderma lingzhi and G. resinaceum by PEG-Induced Double-Inactivated Protoplast Fusion. Jintao Li,Linling Liu,Lin Xu,Sheng Wang,Nan Zhang,Changwei Sun,Meixia Yan. 2023

[11]The Secondary Metabolites and Biosynthetic Diversity From Aspergillus ochraceus. Lin Chen,Erfeng Li,Wenqing Wu,Gang Wang,Jiaqian Zhang,Xu Guo,Fuguo Xing. 2022

[12]FtBPM3 modulates the orchestration of FtMYB11-mediated flavonoids biosynthesis in Tartary buckwheat. Mengqi Ding,Kaixuan Zhang,Yuqi He,Qian Zuo,Hui Zhao,Ming He,Milen I. Georgiev,Sang Un Park,Meiliang Zhou. 2021

[13]An integrated transcriptome and metabolome approach reveals the accumulation of taste-related metabolites and gene regulatory networks during watermelon fruit development. Chengsheng Gong,Hongju Zhu,Xuqiang Lu,Dongdong Yang,Shengjie Zhao,Muhammad Jawad Umer,Nan He,Pingli Yuan,Muhammad Anees,Weinan Diao,M. O. Kaseb,Wenge Liu. 2021

[14]Heat wave event facilitates defensive responses in invasive C3 plant Ambrosia artemisiifolia L. under elevated CO2 concentration to the detriment of Ophraella communa. Tian, Zhenya,Ma, Chao,Zhao, Chenchen,Zhang, Yan,Gao, Xuyuan,Tian, Zhenqi,Chen, Hongsong,Guo, Jianying,Zhou, Zhongshi. 2022

[15]Epigallocatechin-3-Gallate (EGCG): A unique secondary metabolite with diverse roles in plant-environment interaction. Golam Jalal Ahammed,Yaxian Wu,Yameng Wang,Tianmeng Guo,Rubya Shamsy,Xin Li. 2023

[16]A New Ergosterol-Type Steroid Isolated from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus sp. TE-65L. Huang, Xin-Rong,Jiang, Chao-Nan,Si, Tong,Zhang, Peng,Zhang, Zhong-Feng. 2023

[17]Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts. Qiu S.,Yang B.,Li Z.,Li S.,Yan H.,Xin Z.,Liu J.,Zhao X.,Zhang L.,Xiang W.,Wang W.. 2024

[18]Trichoderma-secreted anthranilic acid promotes lateral root development via auxin signaling and RBOHF-induced endodermal cell wall remodeling. Yu Chen,Yansong Fu,Yanwei Xia,Youzhi Miao,Jiahui Shao,Wei Xuan,Yunpeng Liu,Weibing Xun,Qiuyan Yan,Qirong Shen,Ruifu Zhang. 2024

[19]Transcriptome and metabolome analyses reveal the regulation effect of ultraviolet-B irradiation on secondary metabolites in pakchoi. Mao P.,Xu Y.,Qin H.,Sun Q.,Ma C.,Xu Z.,Li Q.,Zheng Y.. 2024

[20]Enhanced Antioxidant Activity and Secondary Metabolite Production in Tartary Buckwheat under Polyethylene Glycol (PEG)-Induced Drought Stress during Germination. Md Shakhawat Hossain,Jing Li,Chenyang Wang,Fakhrul Islam Monshi,Rehenuma Tabassum,Md Ashraful Islam,Muhiuddin Faruquee,Md Abdul Muktadir,Md Sultan Mia,A. K.M.Mominul Islam,Ahmed Khairul Hasan,Ashim Sikdar,Baili Feng. 2024

作者其他论文 更多>>