数字农科院2.0

A Single Amino Acid Residue R144 of SNX16 Affects Its Ability to Inhibit the Replication of Influenza A Virus

文献类型： 外文期刊

作者： Wenjun Shi;Li Jiang;Miaomiao Ye;Bo Wang;Yu Chang;Zhibo Shan;Xuyuan Wang;Yuzhen Hu;Hualan Chen;Chengjun Li

作者机构：

关键词： influenza A virus;R144 residue;replication;SNX16

期刊名称： Viruses

ISSN： 1999-4915

年卷期： 2022 年 14 卷 4 期

页码：

摘要： Influenza A virus (IAV) is an important zoonotic pathogen, posing a severe burden for the health of both animals and humans. Many host factors are involved in the life cycle of IAV to regulate its replication. Herein, we identified sorting nexin-16 (SNX16) as a new host factor that negatively modulates the replication of IAV. When transiently overexpressed in cells, SNX16 appears to be expressed as two obvious bands. Mutagenesis analysis indicated that the amino acid residue R144 of SNX16 was responsible for its two-band expression phenotype. We found that the R144A mutation of SNX16 changed its cellular distribution in A549 cells and partially weakened the inhibitory effect of SNX16 on IAV replication. Further investigation revealed that SNX16 could negatively regulate the early stage of the replication cycle of IAV. Taken together, our results demonstrated that SNX16 is a novel restriction host factor for the replication of IAV by engaging in the early stage of IAV life cycle, and a single amino acid residue at position 144 plays an important role in the cellular distribution and anti-influenza function of SNX16.

分类号：

  • 相关文献

[1]Inter-Fighting between Influenza A Virus NS1 and β-TrCP: A Novel Mechanism of Anti-Influenza Virus. Sun H.,Wang K.,Yao W.,Liu J.,Lv L.,Shi X.,Chen H.. 2022

[2]HACD3 Prevents PB1 from Autophagic Degradation to Facilitate the Replication of Influenza A Virus. Qibing Li,Li Jiang,Yihan Wang,Xuwei Liu,Bo Wang,Zhibo Shan,Yi Han Wang,Yuqin Wang,Hualan Chen,Chengjun Li. 2024

[3]N6-methyladnosine of vRNA facilitates influenza A virus replication by promoting the interaction of vRNA with polymerase proteins. Qian Wang,Shuai Xu,Wentao Shen,Yanli Wei,Lu Han,Zhengxiang Wang,Yingying Yu,Minxuan Liu,Junwen Liu,Guohua Deng,Hualan Chen,Qiyun Zhu. 2025

[4]猪繁殖与呼吸综合征病毒感染和复制机制及其毒力研究进展AdvancesinUnderstandingoftheInfection/ReplicationMechanismsandVirulenceDeterminantsofthePorcineReproductiveandRespiratorySyndromeVirus. 刘杏,王凤雪,温永俊*LIUXing,WANGFengxue,WENYongjun*. 2015

[5]The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis. Wang, Xiaodu,Shen, Yang,Qiu, Yafeng,Shi, Zixue,Shao, Donghua,Chen, Peijun,Tong, Guangzhi,Ma, Zhiyong,Qiu, Yafeng,Shao, Donghua,Ma, Zhiyong. 2010

[6]Influenza a virus NS1 protein induced A20 contributes to viral replication by suppressing interferon-induced antiviral response. Feng, Wenjing,Sun, Xiaoning,Zhang, Maolin,Guan, Zhenhong,Duan, Ming,Shi, Ning.

[7]Structural Definition of Duck Major Histocompatibility Complex Class I Molecules That Might Explain Efficient Cytotoxic T Lymphocyte Immunity to Influenza A Virus. Wu, Yanan,Wang, Junya,Fan, Shuhua,Chen, Rong,Liu, Yanjie,Zhang, Jianhua,Yuan, Hongyu,Liang, Ruiying,Zhang, Nianzhi,Xia, Chun,Liu, Yanjie,Xia, Chun.

[8]Impacts of different expressions of PA-X protein on 2009 pandemic H1N1 virus replication, pathogenicity and host immune responses. Leea, Jinhwa,Yua, Hai,Li, Yonghai,Ma, Jingjiao,Lang, Yuekun,Duff, Michael,Henningson, Jamie,Liu, Qinfang,Li, Yuhao,Nagy, Abdou,Bawa, Bhupinder,Richt, Juergen A.,Ma, Wenjun,Yua, Hai,Liu, Qinfang,Li, Zejun,Tong, Guangzhi,Nagy, Abdou.

[9]Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses. Zhou, Zhen,Li, Xihan,Dong, Lei,Chen, Qun,Liu, Jialing,Hou, Dongxia,Zhang, Lin,Liu, Yuchen,Zhang, Yujing,Li, Jing,Wang, Jin,Chen, Xi,Zhang, Junfeng,Zen, Ke,Zhang, Chen-Yu,Liu, Jinxiong,Kong, Huihui,Zhang, Qianyi,Zhang, Guoquan,Qi, Xian,Wang, Hua. 2015

[10]Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR. Yan An,Zhou ZhenFeng,Dong Hui,Zhang YaKun,Jin Li,Zhao GuoPing,Xiong Hui,Zhu Lei,He YunGang,Zhao GuoPing,Jin WeiRong,Zhang GuoQing,Li YiXue,Yang Zhong,Zhong Yang,Cao ZhiWei,Jin Li,Wang HongYan,Wang XiaoNing,Yang Zhong,Zhong Yang,Zhao GuoPing,Wang XiaoNing,Dai JianXin,Guo YaJun,Wang Hao,Dai JianXin,Guo YaJun,Wang Hao,Che XiaoYan,Wu Fan,Yuan ZhenGan,Zhang Xi,Cao ZhiWei,Zhou XiaoNong,Zhou JiaHai,Ma ZhiYong,Tong GuangZhi,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing,Ding GuoHui,Li YiXue,Sun Bing,Huang Zhong,Lan Ke,Jin Li,Zhao GuoPing. 2009

[11]Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type. Sandbulte, Matthew R.,Roth, James A.,Kitikoon, Pravina,Vincent, Amy L.,Gauger, Phillip C.,Chen, Hongjun,Perez, Daniel R.,Sandbulte, Matthew R.,Kitikoon, Pravina,Chen, Hongjun,Perez, Daniel R..

[12]A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice. Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Sun, Weiyang,Zhang, Xinghai,Li, Yuanguo,Wang, Tiecheng,Wang, Hualei,Xin, Yue,Li, Xue,Zhang, Kun,Huang, Jing,Yang, Songtao,Gao, Yuwei,Xia, Xianzhu,Cheng, Kaihui,Zhang, Qianyi,Chen, Hualan,Wilker, Peter R.,Yue, Donghui,Gao, Yuwei,Xia, Xianzhu,Xia, Xianzhu.

[13]An M2e-based synthetic peptide vaccine for influenza A virus confers heterosubtypic protection from lethal virus challenge. Ma, Ji-Hong,Yang, Fu-Ru,Yu, Hai,Zhou, Yan-Jun,Li, Guo-Xin,Huang, Meng,Wen, Feng,Tong, Guangzhi. 2013

[14]Type I interferon-mediated immune response against influenza A virus is attenuated in the absence of p53. Zhu, Zixiang,Yang, Yifan,Wei, Jianchao,Shao, Donghua,Shi, Zixue,Li, Beibei,Liu, Ke,Qiu, Yafeng,Ma, Zhiyong,Zhu, Zixiang,Zheng, Haixue.

[15]PLC-gamma 1 is involved in the inflammatory response induced by influenza A virus H1N1 infection. Xu, Shuai,Yang, Jiayun,Zhu, Qiyun,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Zhu, Liqian,Yuan, Chen,Ding, Xiuyan,Liang, Yuying.

[16]Simultaneous detection of novel H7N9 and other influenza A viruses in poultry by multiplex real-time RT-PCR. Xu, Xiaolong,Bao, Hongmei,Ma, Yong,Sun, Jiashan,Zhao, Yuhui,Wang, Yunhe,Shi, Jianzhong,Zeng, Xianying,Li, Yanbing,Wang, Xiurong,Chen, Hualan. 2015

[17]A broad protection provided by matrix protein 2 (M2) of avian influenza virus. Meng, Qingwen,Liu, Guangliang,Liu, Yonggang,Wang, Wei,Chen, Hongyan,Deng, Xiaoxia,Xu, Kehui,Zheng, Xiangdong,Zhang, Dongwei,Pang, Hai,Liu, Guangliang.

[18]Co-circulation of pandemic 2009 H1N1, classical swine H1N1 and avian-like swine H1N1 influenza viruses in pigs in China. Chen, Yan,Zhang, Jian,Qiao, Chuanling,Yang, Huanliang,Zhang, Ying,Xin, Xiaoguang,Chen, Hualan. 2013

[19]Age- and sex-associated differences in the glycopatterns of human salivary glycoproteins and their roles against influenza A virus. Qin, Yannan,Zhong, Yaogang,Zhu, Minzhi,Dang, Liuyi,Yu, Hanjie,Chen, Zhuo,Chen, Wentian,Li, Zheng,Wang, Xiurong,Zhang, Hua.

[20]Host Cellular Protein TRAPPC6A Delta Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking. Zhu, Pengyang,Liang, Libin,Shao, Xinyuan,Luo, Weiyu,Jiang, Shuitao,Zhao, Qingqing,Sun, Nan,Zhao, Yuhui,Li, Junping,Wang, Jinguang,Zhou, Yuan,Zhang, Jie,Wang, Guangwen,Jiang, Li,Chen, Hualan,Li, Chengjun.

作者其他论文 更多>>