数字农科院2.0

Riboflavin Deficiency and Apoptosis: A Review

文献类型： 外文期刊

作者： Zhang, Bo;Hou, Shuisheng;Tang, Jing

作者机构：

关键词： riboflavin;apoptosis;mitochondrial pathway;endoplasmic reticulum stress;redox balance

期刊名称： JOURNAL OF NUTRITION

ISSN： 0022-3166

年卷期： 2025 年 155 卷 1 期

页码：

收录情况： SCIE（2025版）

摘要： Riboflavin, commonly known as vitamin B2, is an essential micronutrient critical for the function of flavoproteins, which utilize flavin mononucleotide and flavin adenine dinucleotide as cofactors in energy metabolism, lipid metabolism, redox regulation, and protein folding. Nutritional riboflavin deficiency (RD) has previously been observed in humans and animals, leading to adverse outcomes such as growth retardation, increased mortality, and liver damage, which may be attributed to apoptosis. Although such deficiencies are now uncommon because of improved living standards, certain high-risk groups (e.g. those with chronic diseases, the elderly, and pregnant) have increased riboflavin demands, making them vulnerable to physiological RD associated with apoptosis. Understanding the pathways through which RD induces apoptosis, including mitochondrial dysfunction, endoplasmic reticulum stress, and reactive oxygen species, is essential for grasping its broader health impacts. Additionally, this deficiency disrupts fatty acid metabolism, potentially resulting in lipotoxic apoptosis. Despite its significance, RD-induced apoptosis remains underexplored in the literature. Therefore, this review will discuss the roles of redox imbalance, mitochondrial dysfunction, endoplasmic reticulum stress, and lipotoxicity in apoptosis regulation because of RD, aiming to highlight its importance for improving riboflavin nutrition and overall health.

分类号：

  • 相关文献

[1]Effect of Flammulina velutipes polysaccharide on mitochondrial apoptosis in lung adenocarcinoma A549 cells. Fei Zhao,Dan Yang Chen,Bo Jing,Yu Jiang,Lan Yue Liu,Hui Song. 2024

[2]Maternal riboflavin deficiency causes embryonic defects by activating ER stress-induced hepatocyte apoptosis pathway. Bo Zhang,Kexin Gao,Junting Cao,Guangnan Xing,Zhanqing Ji,Zhinan Li,Yating Li,Jaap Keijer,Ming Xie,Zhengkui Zhou,Shuisheng Hou,Jing Tang. 2024

[3]GRP94 Inhabits the Immortalized Porcine Hepatic Stellate Cells Apoptosis under Endoplasmic Reticulum Stress through Modulating the Expression of IGF-1 and Ubiquitin. Xiaohong Wang,Hairui Xin,Chuang Zhang,Xianhong Gu,Yue Hao. 2022

[4]Riboflavin (Vitamin B2) Deficiency Induces Apoptosis Mediated by Endoplasmic Reticulum Stress and the CHOP Pathway in HepG2 Cells. Bo Zhang,Jun Ting Cao,Yong Bao Wu,Ke Xin Gao,Ming Xie,Zheng Kui Zhou,Jing Tang,Shui Sheng Hou. 2022

[5]XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells. Ziwei Cui,Ruoshan Qin,Jianbao Feng,Yuan Liu,Xiongtao Zhou,Xiaodong Qin,Yanmin Li,Zhidong Zhang,Xiangyi He. 2023

[6]Ryanodine receptor RyR1-mediated elevation of Ca2+ concentration is required for the late stage of myogenic differentiation and fusion. Kai Qiu,Yubo Wang,Doudou Xu,Linjuan He,Xin Zhang,Enfa Yan,Lu Wang,Jingdong Yin. 2022

[7]Plant sterol ester of α-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the AMPK. Hao Han,Tingli Xue,Jie Li,Yan Guo,Xiaoyu Li,Linqi Wang,Liyuan Pei,Mingming Zheng. 2022

[8]Dietary riboflavin supplementation improve the growth performance and antioxidant status of starter white Pekin ducks fed a corn-soybean meal diets. Tang, J.,Wen, Z. G.,Guo, Z. B.,Huang, W.,Xie, M.,Hou, S. S.,Tang, J.,Wen, Z. G.,Guo, Y. M..

[9]Effects of riboflavin supplementation on growth performance, carcass traits, and riboflavin status of growing male white Pekin ducks. Tang, J.,Hu, J.,Wen, Z. G.,Jiang, Y.,Huang, W.,Xie, M.,Hou, S. S.,Tang, J.,Wen, Z. G.,Jiang, Y.,Guo, Y. M.,AL-Kateb, H..

[10]Integrated control of tobacco black shank by combined use of riboflavin and Bacillus subtilis strain Tpb55. Zhang, Chengsheng,Tian, Xueying,Wang, Fenglong,Gao, Jiaming,Han, Teng.

[11]Effects of riboflavin deficiency on the lipid metabolism of duck breeders and duck embryos. B. Zhang,J. Tang,Y. B. Wu,J. T. Cao,G. N. Xing,P. X. Sun,W. Huang,M. Xie,S. S. Hou. 2021

[12]Dietary riboflavin supplementation improves meat quality, antioxidant capacity, fatty acid composition, lipidomic, volatilomic, and proteomic profiles of breast muscle in Pekin ducks. Jing Tang,Bo Zhang,Dapeng Liu,Kexin Gao,Ye Dai,Suyun Liang,Wentao Cai,Zhinan Li,Zhanbao Guo,Jian Hu,Zhengkui Zhou,Ming Xie,Shuisheng Hou. 2023

[13]Effect of riboflavin deficiency on intestinal morphology, jejunum mucosa proteomics, and cecal microbiota of Pekin ducks. Xu Y.,Zhang B.,Zhao R.,Gao K.,Liang S.,Wu Y.,Hao Y.,Liu D.,Guo Z.,Hu J.,Zhou Z.,Xie M.,Tang J.. 2023

[14]Riboflavin-mediated ultraviolet photosensitive oxidation of beef myofibrillar proteins with different storage times. Liangyu Xue,Wensong Wei,Fangting Fu,Huixin Tian,Xiaojia Hu,Chunhui Zhang. 2025

[15]Geographical and genetic insights into riboflavin and its derivatives compositions in 1186 soybean accessions. Aimal Nawaz Khattak,Shengrui Zhang,Kwadwo Gyapong Agyenim-Boateng,Jie Qi,Muhammad Ahsan,Azhar Iqbal,Emmanuel Kofi Sie,Adebabay Tazeb,Bin Li,Jing Li,Junming Sun. 2025

[16]Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2 alpha signaling pathway. Gao, Hui,Yan, Peipei,Han, Hao,Yang, Wei,Yao, Ping,Liu, Liegang,Gao, Hui,Yan, Peipei,Zhang, Shun,Han, Hao,Yang, Wei,Yao, Ping,Liu, Liegang,Nie, Shuke,Huang, Fenghong,Deng, Qianchun,Huang, Qingde,Xu, Jiqu,Huang, Fenghong,Deng, Qianchun,Huang, Qingde,Xu, Jiqu,Wu, Hailei,Ye, Keqiang. 2016

[17]Plant ERD2-like proteins function as endoplasmic reticulum luminal protein receptors and participate in programmed cell death during innate immunity. Li, Sizhun,Xie, Ke,Zhang, Qiang,Wang, Yan,Tang, Yang,Liu, Dong,Liu, Yule,Hong, Yiguo,He, Chenyang. 2012

[18]kappa-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice. Wang, Jing,Yu, Shouyi,Jiao, Shouhai,Du, Yuguo,Jiao, Shouhai,Lv, Xiaowen,Ma, Min. 2013

[19]The Perk Arm Of The U.nfolded Protein Response Negatively R egulates Transmissible Gastroenteritis Virus Replication By Suppressing Protein Translation And Promoting Type I Interferon Production. Xue, M, Fu, F, Ma, YL, Zhang, X, Li, L, Feng, L, Liu, PH. 2018

[20]Viral Infection-Induced Endoplasmic Reticulum Stress A.nd A Membrane-Associated Transcription F actor Nbnac089 Are Involved In Resistance To Virus In Nicotiana Benthamiana. Li, FF, Sun, HJ, Jiao, YB, Wang, FL, Yang, JG, Shen, LL. 2018

作者其他论文 更多>>