数字农科院2.0

Genotyping and Molecular Characterization of Classical Swine Fever Virus Isolated in China during 2016-2018

文献类型： 外文期刊

作者： Fatima Madiha;Luo Yuzi;Zhang Li;Wang Peng-Ying;Song Hao;Fu Yanhui;Li Yongfeng;Sun Yuan;Li Su;Bao Yun-Juan;Qiu Hua-Ji

作者机构：

关键词： antigenicity; classical swine fever virus; genetic typing; molecular characterization; subgenotype 2.1

期刊名称： Viruses

ISSN： 1999-4915

年卷期： 2021 年 13 卷 4 期

页码：

收录情况： JCR（2021版）

摘要： Classical swine fever (CSF) is a highly contagious disease of swine caused by classical swine fever virus (CSFV). For decades the disease has been controlled in China by a modified live vaccine (C-strain) of genotype 1. The emergent genotype 2 strains have become predominant in China in the past years that are genetically distant from the vaccine strain. Here, we aimed to evaluate the current infectious status of CSF, and for this purpose 24 isolates of CSFV were identified from different areas of China during 2016-2018. Phylogenetic analysis of NS5B, E2 and full genome revealed that the new isolates were clustered into subgenotype 2.1d and 2.1b, while subgenotype 2.1d was predominant. Moreover, E2 and Erns displayed multiple variations in neutralizing epitope regions. Furthermore, the new isolates exhibited capacity to escape C-strain-derived antibody neutralization compared with the Shimen strain (genotype 1). Potential positive selection sites were identified in antigenic regions of E2 and Erns, which are related with antibody binding affinity. Recombination events were predicted in the new isolates with vaccine strains in the E2 gene region. In conclusion, the new isolates showed molecular variations and antigenic alterations, which provide evidence for the emergence of vaccine-escaping mutants and emphasize the need of updated strategies for CSF control.

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