数字农科院2.0

Structural analysis and immunological activity of a novel low molecular weight neutral polysaccharide isolated from Hemerocallis citrina Borani

文献类型： 外文期刊

作者： Yongrui Ti;Yanli Zhang;Yuqing Hou;Yuqian Ban;Xiaoxiao Wang;Guoliang Li;Zihan Song

作者机构：

关键词： Hemerocallis citrina Borani;Immunological effect;Low molecular weight neutral polysaccharide;Purification;Structural analysis

期刊名称： Food Chemistry

ISSN： 0308-8146

年卷期： 2025 年 469 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： A novel neutral water-soluble polysaccharide (HCBP1–1) was isolated and purified from Hemerocallis citrina Borani by column chromatography. The fine structure of HCBP1–1 was determined by a series of physical and chemical means. HCBP1–1 was a homogeneous low molecular weight polysaccharide of 7.25 kDa. Methylation and NMR analysis revealed that HCBP1–1 consisted of α-D-Glcp-(1→, →4)-α-D-Glcp-(1→, →4)-β-D-Galp-(1→, →4,6)-α-D-Glcp-(1→, →3,4)-α-D-Glcp-(1→. In particular, the main backbone of HCBP1–1 consisted of unsubstituted (4-α-D-Glcp and 4-β-D-Galp) and monosubstituted (4,6-α-D-Glcp and 3,4-α-D-Glcp) glucose and galactose units linked by α-(1 → 4) and β-(1 → 4) glycosidic linkages. The side chain consisted of α-D-Glcp-(1 → and →4)-α-D-Glcp-(1→. Furthermore, bioactivity assays show that HCBP1–1 significantly promoted the secretion of NO, TNF-α, IL-1β, and IL-6 and the expression of NF-κB p65 in RAW264.7 cells, which had good immune-enhancing activity. These results suggest that HCBP1–1 had beneficial immunomodulatory effects and could be developed into functional foods or nutraceuticals with immune-enhancing properties.

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