数字农科院2.0

Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family

文献类型: 外文期刊

作者: Cui, Chao-Yue;Chen, Qiwei;He, Qian;Chen, Chong;Zhang, Rong-Min;Feng, Youjun;Sun, Jian

作者机构:

关键词: Tet(X);tetracycline;tigecycline resistance;transferability

期刊名称: WIRES MECHANISMS OF DISEASE

ISSN: 2692-9368

年卷期: 2021 年

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收录情况: 不在遴选数据库范围

摘要: Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The emergence of mobile Tet(X) enzymes that destruct tetracycline-type antibiotics is posing a big challenge to antibacterial therapy and food/environmental securities. Here, we present an update on a growing number of Tet(X) variants. We describe structure and action of Tet(X) enzyme, and discuss the evolutional origin. In addition, potential Tet(X) inhibitors are given. This mini-review might benefit better understanding of Tet(X)-mediated tigecycline resistance. This article is categorized under: Infectious Diseases > Genetics/Genomics/Epigenetics Infectious Diseases > Environmental Factors Infectious Diseases > Molecular and Cellular Physiology

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