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Short Communication: Mosquito Histone 2A Protein Facilitate Japanese Encephalitis Virus Infection in the Mosquito

文献类型： 外文期刊

作者： Muddassar, Hameed;Chen, Mengli;Zhang, Tong;Mohsin, Nawaz;Kang, Lei;Zheng, Jiayang;Li, Zongjie;Shao, Donghua;Wei, Jianchao;Li, Beibei;Qiu, Yafeng;Ma, Zhiyong;Liu, Ke

作者机构：

关键词： Japanese encephalitis virus;histone 2A;mosquito

期刊名称： VECTOR-BORNE AND ZOONOTIC DISEASES

ISSN： 1530-3667

年卷期： 2024 年

页码：

收录情况： SCIE（2024版）

摘要： Japanese encephalitis virus is mainly prevalent in the tropical and subtropical regions of Asia and Oceania. Through immunoprecipitation-mass spectrometry analysis using monoclonal antibodies targeting JEV E protein, we found that mosquito Histone 2A protein could bind to JEV particles. The binding of H2A and JEV was detected in the salivary gland and supernatant of mosquito cells. Furthermore, RNA interference experiments in vitro and in vivo confirmed that H2A protein promotes JEV infection in mosquitoes. In summary, we found that mosquito H2A is a factor that supports JEV infection and can potentially facilitate cross-species transmission of JEV.

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