文献类型: 外文期刊
作者: Zhijin Zhang;Mingze Cao;Zixuan Shang;Jing Xu;Xu Chen;Zhen Zhu;Weiwei Wang;Xiaojuan Wei;Xuzheng Zhou;Yubin Bai;Jiyu Zhang
作者机构:
关键词: antibacterial activity;antibacterial mechanism;multidrug-resistant bacteria;natural flavonoids;synergistic effects
期刊名称: Antibiotics
ISSN: 2079-6382
年卷期: 2025 年 14 卷 4 期
页码:
收录情况: SCIE(2025版)
摘要: The use of antibiotics has greatly improved the treatment of bacterial infections; however, its abuse and misuse has led to a rapid rise in multidrug-resistant (MDR) bacteria. Therefore, the search for new antimicrobial strategies has become critical. Natural flavonoids, a class of widely existing phytochemicals, have gained significant research interest for their diverse biological activities and antibacterial effects on various drug-resistant bacteria. This review summarizes the latest research progress on flavonoids, with a particular focus on several flavonoids exhibiting certain antibacterial activity, and explores their antibacterial mechanisms, including disruption of cell membranes and cell walls, inhibition of proteins and nucleic acids, interference with signal transduction, suppression of efflux pump activity, and inhibition of biofilm formation and virulence factor production. Additionally, we have reviewed the synergistic combinations of flavonoids with antibiotics, such as the combination of quercetin with colistin or EGCG with tetracycline, which significantly enhance therapeutic efficacy.
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